Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology
Possible role of cortisol and dehydroepiandrosterone in human development and psychopathology
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DOI：
10.1192/bjp.179.3.243
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发表时间：
2001-09-01
影响因子：
10.5
通讯作者：
Herbert, J
中科院分区：
文献类型：
--
作者：
Goodyer, IM;Park, RJ;Herbert, J
背景肾上腺激素分泌的特征在婴儿期发生显著变化。基础水平的紊乱可能会导致心理功能障碍，并与年轻人的精神病理学有关。皮质醇和脱氢表雄酮（DHEA）的发育变化，这些激素在年轻人精神病理学中的作用，和行动，这些类固醇在brain.Method从人类发育，精神病学和神经科学literature.Results有选择性的审查有发育介导的变化，大脑的敏感性过度暴露于皮质醇。这可能导致精神和行为功能受损。脱氢表雄酮和性腺类固醇激素可以调节的行动cortisol.Conclusions类固醇激素有助于塑造行为功能在早期发展和作为危险因素的psychopathology.Declaration的利益支持的惠康信托基金，医学研究理事会和生物技术和生物科学研究理事会。
Background The characteristics of adrenal hormone secretion change markedly during infancy Disturbances in basal levels may precipitate psychological dysfunction and are associated with psychopathology in young people.Aims To relate three aspects of behavioural endocrinology: developmental changes in cortisol and dehydroepiandrosterone (DHEA), the role of these hormones in the psychopathology of young people, and the action of these steroids in the brain.Method A selective review from the human developmental, psychiatric and neurosciences literature.Results There are developmentally mediated changes in brain sensitivity following excess exposure to cortisol. This may result in impairments of mental and behavioural function. DHEA and gonadal steroids may modulate the actions of cortisol.Conclusions Steroid hormones contribute to shaping behavioural function during early development and act as risk factors for psychopathology.Declaration of interest Supported by the Wellcome Trust, the Medical Research Council and the Biotechnology and Biological Sciences Research Council.