Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures
Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures
复制标题
通过铝诱导形成主链环结构使蛋白质发生不可逆变性
DOI：
10.1002/anie.201307955
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发表时间：
2014-06-01
影响因子：
16.6
通讯作者：
Fang, Haiping
中科院分区：
文献类型：
--
作者：
Song, Bo;Sun, Qian;Fang, Haiping
从头计算、圆二色性、核磁共振和x射线光电子能谱的结合表明，铝离子可以诱导多种多肽中主链环结构的形成，包括神经退行性疾病相关基序。这些环结构极大地破坏了蛋白质的稳定性，并导致不可逆的变性。这种行为得益于铝离子与肽主链上的酰胺氮和羰基氧原子同时形成化学键的能力。
A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.