A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8(+) T cells.
A striking property of recombinant poxviruses: efficient inducers of in vivo expansion of primed CD8(+) T cells.
复制标题
重组痘病毒的一个显着特性是：能够有效诱导已启动的 CD8(+) T 细胞在体内扩增。
DOI：
10.1006/viro.2000.0792
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Esteban,M
中科院分区：
文献类型：
--
作者：
Zavala,F;Rodrigues,M;Rodriguez,D;Rodriguez,JR;Nussenzweig,RS;Esteban,M
Over 200 years ago, in 1796, Jenner introduced vaccination, a name coined by Pasteur, as an effective means to control one of the most devastating diseases of mankind, smallpox. Since then, a large number of vaccines have been developed against many microbial pathogens based on the use of live attenuated, heat-killed, or otherwise inactivated microorganisms or their toxins (Plotkin, 1993). The main protective mechanisms elicited by these vaccines are neutralizing antibodies. After multiple doses of the same immunogen, the titers of antibodies as well as their avidity increase, conferring maximal protection. This strategy is used to induce large antibody responses to intracellular pathogens such as viruses, certain bacteria, fungi, and protozoans. Currently available vaccines, particularly those based on live attenuated carriers, like poxvirus recombinants, can also induce cell-mediated immunity which protects against certain viral diseases (Moss, 1996). However, the evaluation of the magnitude, duration, and efficacy of the CD8+ T cell immune responses induced by these immunogens has been difficult to ascertain in humans due to the limited availability of appropriate, quantitative, antigenspecific methods.Recent advances in biotechnology have made it feasible to identify and produce recombinant proteins expressing key microbial antigens/epitopes. This has been particularly important in the case of pathogens that have proven to be difficult if not impossible to grow in vitro. The corresponding subunit vaccine candidates are being produced as recombinant or synthetic polypeptides, DNA, as well as recombinant bacterial or viral vectors capable of inducing antibodies as well as T cell re-
