Neuroanatomical substrates of late-life minor depression - A quantitative magnetic resonance imaging study
Neuroanatomical substrates of late-life minor depression - A quantitative magnetic resonance imaging study
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DOI：
10.1001/archneur.1997.00550170085018
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发表时间：
1997-05-01
影响因子：
--
通讯作者：
Gottlieb, G
中科院分区：
文献类型：
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作者：
Kumar, A;Schweizer, E;Gottlieb, G
目的：目的：研究老年轻度抑郁症患者的神经解剖学相关性，采用磁共振成像技术。设计：对老年轻度抑郁症患者和年龄匹配的对照组进行横断面定量磁共振成像研究。设置：患者和对照组通过广告从社区招募到费城宾夕法尼亚大学老年精神病学科。参与者：我们的样本包括18名被诊断为患有轻度抑郁症的受试者，使用修改后的精神疾病诊断和统计手册，第四版，研究标准和31名对照无抑郁症。患者均无其他中枢神经系统疾病，两组患者的医学合并症程度相当。主要结果测量：所有图像均在1.5 T扫描仪上获得，并对两组之间的全局和局灶性脑和脑脊液体积进行绝对和标准化定量测量。在控制了年龄、性别和年龄与性别的相互作用后，轻度抑郁组的前额叶体积显著小于对照组（P= 0.002）。更多的全球性措施的大脑和脑脊液的体积在两个group.Conclusion：这些数据表明，局灶性前额叶萎缩可能提供了一个重要的神经解剖基板在晚年的轻微抑郁症。
Objective: To examine the neuroanatomical correlates of late-life minor depression using magnetic resonance imaging.Design: Cross-sectional quantitative magnetic resonance imaging study of elderly patients with minor depression and age-matched controls.Setting: Patients and controls were recruited from the community through advertisements to the Section of Geriatric Psychiatry, University of Pennsylvania, Philadelphia.Participants: Our sample included 18 subjects diagnosed as having minor depression using the modified Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, research criteria and 31 controls without depression. Patients were free of other central nervous system disease and both groups had comparable degrees of medical comorbidity.Main Outcome Measures: All images were acquired on a 1.5-T scanner and absolute and normalized quantitative measures of global and focal brain and cerebrospinal fluid volumes were compared between groups.Results: Prefrontal lobe volume was significantly smaller in the group with minor depression (P=.002) compared with controls after controlling for age, sex, and age by sex interactions. More global measures of brain and cerebrospinal fluid volumes were comparable in both groups.Conclusion: These data suggest that focal prefrontal atrophy may provide an important neuroanatomical substrate in late-life minor depression.