Therapeutic perspectives of heat shock proteins and their protein -protein interactions in myocardial infarction
Therapeutic perspectives of heat shock proteins and their protein -protein interactions in myocardial infarction
复制标题
热休克蛋白及其蛋白质-蛋白质相互作用在心肌梗死中的治疗前景。
DOI：
10.1016/j.phrs.2020.105162
复制
发表时间：
2020-10-01
影响因子：
9.3
通讯作者：
Cheng, Yuanyuan
中科院分区：
文献类型：
--
作者：
Wu, Junxuan;Chen, Sixuan;Cheng, Yuanyuan
心肌梗死（MI）是全球人类死亡的主要原因之一。热休克蛋白（Heat shock proteins, HSPs）是一大家族的保守蛋白，作为分子伴侣，能促进蛋白质正确折叠，维持蛋白质稳定，调节细胞代谢、细胞稳态等生物过程。值得注意的是，热休克蛋白参与了mi相关的病理生理，如细胞凋亡、炎症反应和氧化应激。在此，我们回顾了最近的研究，系统地总结了热休克蛋白在心肌梗死和心肌缺血/再灌注损伤（MIRI）中的作用，并讨论了热休克蛋白复合物的直接和间接蛋白-蛋白相互作用（PPI）在心肌梗死的病理生理和治疗策略中的作用。全面了解HSP复合物的PPIs在心肌梗死中的心脏保护作用，可以为MI或MIRI的治疗提供新的见解。
Myocardial infarction (MI) is one of major causes of human death around the world. Heat shock proteins (HSPs) are a large family of conserved proteins, which can promote correct protein folding, maintain protein stability, and regulate cell metabolism, cellular homeostasis and other biological processes as molecular chaperones. Notable, HSPs are involved in MI-related pathophysiology, such as apoptosis, inflammatory response and oxidative stress. Here, we review recent studies and systematically summarize the role of HSPs in MI and myocardial ischemia/reperfusion injury (MIRI) and discuss the role of direct and indirect protein-protein interactions (PPI) of HSP complexes in the pathophysiology and therapeutic strategies of myocardial infarction. A comprehensive understanding of the cardioprotective role of PPIs of HSP complexes in myocardial infarction can provide new insights for MI or MIRI therapy.