The Impact of Reduced Injected Radioactivity on Image Quality of Molecular Breast Imaging Tomosynthesis.
The Impact of Reduced Injected Radioactivity on Image Quality of Molecular Breast Imaging Tomosynthesis.
复制标题
降低的注入放射性对分子乳房成像的图像质量的影响。
DOI：
10.1007/978-3-642-31271-7_39
复制
发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Williams MB
中科院分区：
文献类型：
--
作者：
Sullivan O;Gong Z;Klanian K;Patel T;Williams MB
本研究的目的是比较图像质量的三维分子乳腺成像断层合成（MBIT）与平面分子乳腺成像（MBI）的乳腺放射性浓度范围内。使用明胶和点源幻影病变对比度，病变的信噪比（SNR）和空间分辨率进行了比较，病变的大小和深度的范围。对于MBI和MBIT，病变对比度基本上是恒定的，而SNR在100%和25%活动水平之间降低1.5 - 2倍。对于几乎所有的病变大小和位置，MBIT的对比度和SNR显著高于MBI，可能允许更大的注射剂量减少。MBI的空间分辨率依赖于病变深度，但与MBIT的病变位置无关。重建的MBIT空间分辨率是实质上优于投影图像中，这表明未来使用更高灵敏度的准直器，甚至进一步减少注入的活动。
This study’s objective is to compare image quality in 3-D molecular breast imaging tomosynthesis (MBIT) with that in planar molecular breast imaging (MBI) over a range of breast radioactivity concentrations. Using gelatin and point source phantoms lesion contrast, lesion signal-to-noise ratio (SNR) and spatial resolution were compared for a range of lesion sizes and depths. For both MBI and MBIT, lesion contrast is essentially constant with changing activity while SNR decreases by a factor of 1.5 – 2 between 100% and 25% activity levels. For nearly all lesion sizes and locations contrast and SNR are significantly higher for MBIT than MBI, potentially permitting greater reductions in injected dose. Spatial resolution in MBI is dependent on lesion depth but independent of lesion location with MBIT. Reconstructed MBIT spatial resolution is substantially better than that in the projection images, suggesting future use of higher sensitivity collimators for even further reductions in injected activity.