Comparing human exposure to emerging and legacy flame retardants from the indoor environment and diet with concentrations measured in serum
Comparing human exposure to emerging and legacy flame retardants from the indoor environment and diet with concentrations measured in serum
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DOI：
10.1016/j.envint.2014.10.003
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发表时间：
2015-01-01
影响因子：
11.8
通讯作者：
Thomsen, Cathrine
中科院分区：
文献类型：
--
作者：
Cequier, Enrique;Maria Marce, Rosa;Thomsen, Cathrine
这项研究调查了46名挪威妇女新出现的和遗留的卤化阻燃剂(HFRS)的血清浓度与HFRS室内空气和粉尘浓度的测量以及有关饮食和家庭因素的详细信息之间的关系。约50%的样品中检出六溴苯(中位数0.03 ng/g油脂)和十氯烷602(中位数0.18 ng/g油脂)，超过78%的样品中检出十氯烷+SYN(中位数0.45 ng/g油脂)和抗(中位数0.85 ng/g油脂)。最丰富的多溴二苯醚是2，2‘，4，4’，5，5‘-六溴联苯醚(BDE-153，中位数0.82 ng/g脂肪)和2，2’，4，4‘-四溴联苯醚(BDE-47，中位数0.49 ng/g脂肪)，在超过70%的样品中检测到。在双变量分析中，生物监测数据与室内空气和粉尘中的测量浓度之间没有一致的关联。另一方面，特定食物的消费量(主要是羊肉/羊肉和人造黄油)与两个以上的HFR血清浓度显著相关，而家庭因素(电子设备)则不是这样。多元线性回归分析仅证实了与饮食有显著相关性的二元变量，这可能表明与室内环境相比，食物对这些肾综合征出血热患者身体负荷变化的贡献更大。(C)2014爱思唯尔有限公司。保留所有权利。
This study investigates associations between serum concentrations of emerging and legacy halogenated flame retardants (HFRs) in 46 Norwegian women and measured indoor air and dust concentrations of the HFRs as well as detailed information on diet and household factors. Hexabromobenzene (median 0.03 ng/g lipid) and Dechlorane 602 (median 0.18 ng/g lipid) were detected in about 50% of the samples and Dechlorane Plus syn (median 0.45 ng/g lipid) and anti (median 0.85 ng/g lipid) in more than 78%. The most abundant polybrominated diphenyl ethers were 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153; median 0.82 ng/g lipid) and 2,2',4,4'-tetrabromodiphenyl ether (BDE-47; median 0.49 ng/g lipid) detected in more than 70% of the samples. In the bivariate analysis, no consistent associations were observed between the biomonitoring data and measured concentrations in indoor air and dust On the other hand, consumption of specific food items (mainly lamb/mutton and margarine) correlated significantly with more than two HFR serum concentrations, while this was not the case for household factors (electronic appliances). Only the significant bivariate associations with diet were confirmed by multivariate linear regression analyses, which might indicate a higher contribution from food compared to the indoor environment to the variation of the body burden of these HFRs. (C) 2014 Elsevier Ltd. All rights reserved.