Age and gender affect likely manometric diagnosis: Audit of a tertiary referral hospital clinical esophageal manometry service
Age and gender affect likely manometric diagnosis: Audit of a tertiary referral hospital clinical esophageal manometry service
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DOI：
10.1111/j.1440-1746.2008.05561.x
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发表时间：
2009-01-01
影响因子：
4.1
通讯作者：
Fraser, Robert J.
中科院分区：
文献类型：
--
作者：
Andrews, Jane M.;Heddle, Richard;Fraser, Robert J.
背景和目的：了解患者的人口统计学资料、常见诊断和这些之间的关联可能会改善测压检查的使用和解释。因此，本研究的目的是确定是否年龄和/或性别影响测压诊断在临床motivationservice.Methods：审计的所有452临床测压报告从2003年12月至2005年7月发出的年龄，性别和诊断进行。患者按年龄（17-24岁n = 14，25-44岁n = 87，45-64岁n = 216和>= 65岁n = 135），性别和数据使用列联表进行比较。男性更有可能有“强迫性”运动问题，P=0.01。随着年龄的增长，正常的运动功能变得不那么常见（P=0.013），非特异性运动障碍、无效/低血压蠕动和“失弛缓样”状况变得更加常见（个体P = NS）。随着年龄的增长，痉挛性运动障碍的发病率呈上升趋势（P = 0.06）。然而，性别并不影响运动是否异常（P = 0.5），痉挛（P = 0.7）或是否存在非特异性运动障碍（P = 0.1）。在总队列中，主要的测压诊断为：非特异性运动障碍33%，运动正常29%，低基础下食管括约肌压力18%，膨胀/无效性痉挛10%，失弛缓症/失弛缓样6%，弥漫性食管痉挛3%，其他1%。男性和女性的功能障碍率相似，尽管“低压问题”在男性中更常见。
Background and Aim: Awareness of patient demographics, common diagnoses and associations between these may improve the use and interpretation of manometric investigations. The aim of the present study therefore was to determine whether age and/or gender affect manometric diagnosis in a clinical motility service.Methods: An audit of all 452 clinical manometry reports issued from December 2003 to July 2005 with respect to age, gender and diagnosis was carried out. Patients were divided by age (17-24 years n = 14, 25-44 years n = 87, 45-64 years n = 216 and >= 65 years n = 135), and gender and data compared using contingency tables.Results: Women were more commonly referred overall (59%) and in each age bracket except < 25 years (64% male). Men were more likely to have 'hypotensive' motor problems P=0.01. With aging, normal motor function became less common (P=0.013), with non-specific motor disorder, ineffective/hypotensive peristalsis and 'achalasia-like' conditions each more common (individual P = NS). Increasing age showed a trend for increased spastic motor disorders (P = 0.06). Gender did not, however, influence whether motility was abnormal (P = 0.5), spastic (P = 0.7) or whether a non-specific motor disorder was present (P = 0.1). In the total cohort, the principal manometric diagnoses were: nonspecific motor disorder 33%, normal motility 29%, low basal lower esophageal sphincter pressure 18%, hypotensive/ineffective peristalsis 10%, achalasia/achalasia-like 6%, diffuse esophageal spasm 3% and other 1%.Conclusions: Aging leads to increasing esophageal motor abnormalities. Men and women have similar rates of dysfunction, although 'low-pressure problems' were more common in men.