5-Aminosalicylic Acid Interferes in the Cell Cycle of Colorectal Cancer Cells and Induces Cell Death Modes
5-Aminosalicylic Acid Interferes in the Cell Cycle of Colorectal Cancer Cells and Induces Cell Death Modes
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DOI：
10.1002/ibd.21086
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发表时间：
2010-03-01
影响因子：
4.9
通讯作者：
Verspaget, Hein W.
中科院分区：
文献类型：
--
作者：
Koelink, Pim J.;Mieremet-Ooms, Marij A. C.;Verspaget, Hein W.
简介：流行病学数据表明，5-氨基水杨酸（5-阿萨），一种用于治疗炎症性肠病的非甾体类抗炎药，可预防这些患者的结直肠癌发展，尽管其机制仍不完全清楚。方法和结果：在这里，我们报告5-阿萨通过干扰细胞周期，即，S期和G2/M期阻滞，依赖于5-阿萨剂量和浓度，以及有丝分裂指数增加。此外，延长细胞周期停滞，反复5-阿萨治疗诱导凋亡，并导致异常的纺锤体组织导致有丝分裂灾难，另一种形式的细胞death.Conclusion：这些观察结果表明，5-阿萨具有化学预防和化疗的属性。
Introduction: Epidemiological data suggests that 5-aminosalicyclic acid (5-ASA), a nonsteroidal antiinflammatory drug used in the treatment of inflammatory bowel diseases, prevents colorectal cancer development in these patients, although the mechanisms remain incompletely understood.Methods and Results: Here we report that 5-ASA prevents growth of several colorectal cancer cell lines by interfering in the cell cycle, i.e., an S-phase and G2/M phase arrest, dependent on 5-ASA dosage and concentration, together with an increased mitotic index. In addition, prolonged cell cycle arrest by repeated 5-ASA treatment induced apoptosis and caused abnormal spindle organization leading to mitotic catastrophe, another form of cell death.Conclusion: These observations illustrate that 5-ASA has chemopreventive and chemotherapeutic properties.