A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens
A study of acute respiratory disease in the community of Port Chalmers. II. Influenza A/Port Chalmers/1/73: intrafamilial spread and the effect of antibodies to the surface antigens
复制标题
查尔莫斯港社区急性呼吸道疾病的研究。
作者：
L. Jennings;J. Miles
在新西兰查尔默斯港半隔离社区进行的呼吸道疾病研究的第一年期间，发生了临床流感流行病，从中分离出甲型流感病毒/查尔默斯港/1/73（H3 N2）变体。在一组选定的26个家庭中，59（46%）的成员有感染的临床或实验室证据。在家庭内传播中，学龄儿童的感染率最高（77%），其次是女性成人（67%），婴儿（64%）和男性成人（41%）。每个家庭的指数感染是学龄儿童10次，表明该年龄组在该社区甲型流感传播中的作用。二次发作率（SAR）为58.3%，高于预期。在1973年流行前采集的血清中，59%的家庭成员可检测到A/England/42/72的HI抗体和25%的NI抗体，而38%的家庭成员可检测到A/Port查尔默斯/ 1/73的HI抗体和8%的NI抗体。本文还讨论了抗体与感染频率的关系。
SUMMARY During the first year of a study of respiratory disease in the semi-isolated community of Port Chalmers, New Zealand, an epidemic of clinical influenza occurred from which the variant influenza A/Port Chalmers/1/73 (H3N2) was isolated. Within a selected group of 26 families, 59 (46%) members had clinical or laboratory evidence of infection. During intrafamilial spread the infection frequency was highest for school-aged children (77%), followed by female adults (67%), infants (64%) and male adults (41%). The index infection in each family was a school-age child on 10 occasions, suggesting the role of this age group in the transmission of influenza A in this community. The secondary attack rate (SAR) of 58·3% was higher than expected. In sera taken before the 1973 epidemic, 59% of family members had detectable HI antibody and 25% NI antibody to A/England/42/72 while 38% had detectable HI antibody and 8% NI antibody to A/Port Chalmers/ 1/73. The relation between pre-existing antibody and infection frequency is discussed.