Portal Vein Thrombosis and Survival in Patients with Cirrhosis
Portal Vein Thrombosis and Survival in Patients with Cirrhosis
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DOI：
10.1002/lt.21941
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发表时间：
2010-01-01
影响因子：
4.6
通讯作者：
Pelletier, Shawn J.
中科院分区：
文献类型：
--
作者：
Englesbe, Michael J.;Kubus, James;Pelletier, Shawn J.
闭塞性门静脉血栓形成（PVT）对肝硬化患者生存的影响尚不清楚。这是一项单中心回顾性队列研究。主要暴露变量是闭塞性pvt的存在。主要结局指标是时间依赖性死亡率。共分析了3295例患者，其中148例（4.5%）有pvt。从肝移植评估时间开始预测死亡率的独立变量包括年龄[危险比（HR）， 1.02；95%可信区间（CI）， 1.01-1.03]，终末期肝病模型（MELD）评分（HR, 1.10; 95% CI, 1.08-1.11），丙型肝炎（HR, 1.44; 95% CI, 1.24-1.68）和PVT （HR, 2.61; 95% CI, 1.97-3.51）。与肝移植时间死亡风险独立相关的变量包括年龄（HR, 1.02; 95% CI, 1.01-1.03）、移植（HR, 0.65; 95% CI, 0.50-0.81）、MELD （HR, 1.08; 95% CI, 1.06-1.10）、丙型肝炎（HR, 1.50; 95% CI, 1.18-1.90）和PVT （1.99; 95% CI, 1.25-3.16）。肝移植时存在闭塞性PVT与30天死亡风险增加相关（优势比，7.39;95% CI, 2.39-22.83）。总之，肝硬化合并PVT患者的死亡风险增加。中华肝脏杂志，2010(4):83-90。(c) 2009 AASLD。
The effects of occlusive portal vein thrombosis (PVT) on the survival of patients with cirrhosis are unknown. This was a retrospective cohort study at a single center. The main exposure variable was the presence of occlusive PVT. The primary outcome measure was time-dependent mortality. A total of 3295 patients were analyzed, and 148 (4.5%) had PVT. Variables independently predictive of mortality from the time of liver transplant evaluation included age [hazard ratio (HR), 1.02; 95% confidence interval (CI), 1.01-1.03], Model for End-Stage Liver Disease (MELD) score (HR, 1.10; 95% CI, 1.08-1.11), hepatitis C (HR, 1.44; 95% CI, 1.24-1.68), and PVT (HR, 2.61; 95% CI, 1.97-3.51). Variables independently associated with the risk of mortality from the time of liver transplant listing included age (HR, 1.02; 95% CI, 1.01-1.03), transplantation (HR, 0.65; 95% CI, 0.50-0.81), MELD (HR, 1.08; 95% CI, 1.06-1.10), hepatitis C (HR, 1.50; 95% CI, 1.18-1.90), and PVT (1.99; 95% CI, 1.25-3.16). The presence of occlusive PVT at the time of liver transplantation was associated with an increased risk of death at 30 days (odds ratio, 7.39; 95% CI, 2.39-22.83). In conclusion, patients with cirrhosis complicated by PVT have an increased risk of death. Liver Transpl 16:83-90, 2010. (c) 2009 AASLD.