ASYMMETRY IN PRIMARY AUDITORY CORTEX ACTIVITY IN TINNITUS PATIENTS AND CONTROLS
ASYMMETRY IN PRIMARY AUDITORY CORTEX ACTIVITY IN TINNITUS PATIENTS AND CONTROLS
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DOI：
10.1016/j.neuroscience.2013.10.015
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发表时间：
2014-01-03
期刊：
影响因子：
3.3
通讯作者：
van Dijk, P.
中科院分区：
文献类型：
--
作者：
Geven, L. I.;de Kleine, E.;van Dijk, P.
耳鸣是一种令人烦恼的幻音感受器，其神经关联尚未解开。以前发表的论文，使用[F-18]-氟-脱氧葡萄糖正电子发射断层扫描（FDG-PET），表明耳鸣患者左初级听觉皮层的代谢增加。这种单侧多动症已被用作局部治疗的目标，如经颅磁刺激。本研究的目的是测试听觉皮层的左侧活动过度是否是耳鸣特有的，或者是与耳鸣无关的听觉系统的一般特征。因此，FDG-PET被用来测量20名耳鸣患者的脑代谢，并将其结果与19名无耳鸣的对照组进行比较。与我们的预期相反，没有与耳鸣相关的多动症。尽管如此，左侧初级听觉皮层的活动高于右侧初级听觉皮层，但这种不对称性在耳鸣患者和对照组中都存在。相反，次级听觉皮层的偏侧化则相反，右侧半球的激活程度更高。这些数据表明，听觉皮层的代谢休息活动存在半球不对称性，但这些与耳鸣无关，是正常大脑的正常特征。(C)2013年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Tinnitus is a bothersome phantom sound percept and its neural correlates are not yet disentangled. Previously published papers, using [F-18]-fluoro-deoxyglucose positron emission tomography (FDG-PET), have suggested an increased metabolism in the left primary auditory cortex in tinnitus patients. This unilateral hyperactivity has been used as a target in localized treatments such as transcranial magnetic stimulation. The purpose of the current study was to test whether left-sided hyperactivity in the auditory cortex is specific to tinnitus or is a general characteristic of the auditory system unrelated to tinnitus. Therefore, FDG-PET was used to measure brain metabolism in 20 tinnitus patients and to compare their results to those in 19 control subjects without tinnitus. In contrast to our expectation, there was no hyperactivity associated with tinnitus. Nevertheless, the activity in the left primary auditory cortex was higher than in the right primary auditory cortex, but this asymmetry was present in both tinnitus patients and control subjects. In contrast, the lateralization in secondary auditory cortex was opposite, with higher activation in the right hemisphere. These data show that hemisphere asymmetries in the metabolic resting activity of the auditory cortex are present, but these are not associated with tinnitus and are a normal characteristic of the normal brain. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.