Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese
Association study of G protein-coupled receptor kinase 4 gene variants with essential hypertension in northern Han Chinese
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DOI：
10.1111/j.1469-1809.2006.00278.x
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发表时间：
2006-11-01
影响因子：
1.9
通讯作者：
Gu, Dongfeng
中科院分区：
文献类型：
--
作者：
Wang, Yaping;Li, Biao;Gu, Dongfeng
为探讨G蛋白偶联受体激酶4（GRK 4）基因（R65 L、A142 V和A486 V）多态性与北方汉族原发性高血压的关系，我们对503例原发性高血压（HT）患者和490例年龄、性别和地区匹配的血压正常（NT）对照者进行了病例对照研究。通过PCR-RFLP分析对三种GRK 4变体进行基因分型。单倍型和单位点分析用于处理基因分型数据。A486等位基因与HT有显著相关性（P < 0.001）。在整个人群中共观察到6种单倍型，其中L-V-A和R-A-A单倍型与高血压显著相关（P = 0.001）。
To investigate the association between polymorphisms in the G protein-coupled receptor kinase 4 gene (GRK4) (R65L, A142V and A486V) and essential hypertension in northern Han Chinese, we conducted a case-control study consisting of 503 individuals with essential hypertension (HT) and 490 age-, gender-, and area-matched normotensive (NT) controls. The three GRK4 variants were genotyped by PCR-RFLP analysis. Both haplotype and single locus analysis were used to process the genotyping data. The A486 allele showed a significant association with HT (P < 0.001). A total of 6 haplotypes were observed in the entire population, with the haplotypes L-V-A and R-A-A being found to be significantly related to hypertension (P = 0.001).