Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria.
Beta-lactamase induction and cell wall metabolism in Gram-negative bacteria.
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DOI：
10.3389/fmicb.2013.00128
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发表时间：
2013
影响因子：
5.2
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Zeng X;Lin J
β-内酰胺酶（降解β-内酰胺抗生素的酶）的产生是抗生素耐药性最普遍和最具威胁性的机制。在过去，广泛的研究集中在β-内酰胺酶的结构，功能和生态，而有限的努力放在β-内酰胺酶的调控机制。最近，越来越多的证据表明，β-内酰胺酶诱导和革兰氏阴性菌细胞壁代谢之间的直接联系。具体地，β-内酰胺酶的表达可以由释放的胞壁素片段（例如胞壁肽）诱导。本文总结了当前对细胞壁代谢、β-内酰胺类抗生素和β-内酰胺酶的认识。特别是，我们全面回顾了最近的研究，通过两个主要的分子机制（AmpG-AmpR-AmpC途径和BlrAB样双组分调节系统）在革兰氏阴性菌中的胞肽诱导β-内酰胺酶。β-内酰胺酶诱导的信号通路为发现用于联合治疗的新抗菌药物提供了广泛的有希望的靶点。因此，为了开发针对广泛的β-内酰胺耐药性的有效缓解策略，高度保证检查细胞壁片段诱导β-内酰胺酶的分子基础。
Production of beta-lactamases, the enzymes that degrade beta-lactam antibiotics, is the most widespread and threatening mechanism of antibiotic resistance. In the past, extensive research has focused on the structure, function, and ecology of beta-lactamases while limited efforts were placed on the regulatory mechanisms of beta-lactamases. Recently, increasing evidence demonstrate a direct link between beta-lactamase induction and cell wall metabolism in Gram-negative bacteria. Specifically, expression of beta-lactamase could be induced by the liberated murein fragments, such as muropeptides. This article summarizes current knowledge on cell wall metabolism, beta-lactam antibiotics, and beta-lactamases. In particular, we comprehensively reviewed recent studies on the beta-lactamase induction by muropeptides via two major molecular mechanisms (the AmpG–AmpR–AmpC pathway and BlrAB-like two-component regulatory system) in Gram-negative bacteria. The signaling pathways for beta-lactamase induction offer a broad array of promising targets for the discovery of new antibacterial drugs used for combination therapies. Therefore, to develop effective mitigation strategies against the widespread beta-lactam resistance, examination of the molecular basis of beta-lactamase induction by cell wall fragment is highly warranted.
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影响因子：
5.2
作者：
Avison, MB;Niumsup, P;Bennett, PM
通讯作者：
Bennett, PM
影响因子：
5.2
作者：
Avison, MB;Niumsup, P;Bennett, PM
通讯作者：
Bennett, PM
影响因子：
3.6
作者：
BARTOWSKY, E;NORMARK, S
通讯作者：
NORMARK, S
影响因子：
3.2
作者：
Cheng, QM;Li, HS;Park, JT
通讯作者：
Park, JT
影响因子：
3.2
作者：
de Pedro, MA;Donachie, WD;Schwarz, H
通讯作者：
Schwarz, H