The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale
The Clinically Important Difference on the Unified Parkinson's Disease Rating Scale
复制标题
DOI：
10.1001/archneurol.2009.295
复制
发表时间：
2010-01-01
影响因子：
--
通讯作者：
Weiner, William J.
中科院分区：
文献类型：
--
作者：
Shulman, Lisa M.;Gruber-Baldini, Ann L.;Weiner, William J.
目标：为了确定统一帕金森病评定量表（UNITED Parkinson's Disease Rating Scale，PDRS）的最小、中等和较大临床重要差异（CID）的估计值，设计：使用基于分布和锚点的方法，基于以下3个外部标准，对帕金森病（PD）患者进行PDRS总分和运动评分的CID的横断面分析：残疾（Schwab和England日常生活活动量表上的10%），疾病阶段（Hoehn和Yahr量表1级）和生活质量（12项健康调查简表的1个标准差）。设置：马里兰州大学帕金森病和运动障碍中心，患者：结果：最小CID为2.3 ~ 2.7分，在PDRS运动评分和PDRS总分上为4.1 ~ 4.5分。中度CID的ADORS运动评分为4.5至6.7分，ADORS总分为8.5至10.3分。一个大的CID是10.7至10.8分的OHSAS运动评分和16.4至17.8 OHSAS总score.Conclusions：一致性之间的多个方法的分析的基础上的主观和客观的数据显示，合理的估计为CID的OHSAS运动评分为2.5分的最小，5.2为中度，和10.8为大的CID。最小CID患者的CIDRS总分估计值为4.3分，中度CID为9.1分，大型CID为17.1分。这些估计值将有助于确定PD进展和对治疗干预的反应的有临床意义的变化。
Objective: To determine the estimates of minimal, moderate, and large clinically important differences (CIDs) for the Unified Parkinson's Disease Rating Scale (UPDRS).Design: Cross-sectional analysis of the CIDs for UPDRS total and motor scores was performed on patients with Parkinson disease (PD) using distribution-and anchor-based approaches based on the following 3 external standards: disability (10% on the Schwab and England Activities of Daily Living Scale), disease stage (1 stage on the Hoehn and Yahr Scale), and quality of life (1 SD on the 12-Item Short Form Health Survey).Setting: University of Maryland Parkinson Disease and Movement Disorders Center,Patients: Six hundred fifty-three patients with PD.Results: A minimal CID was 2.3 to 2.7 points on the UPDRS motor score and 4.1 to 4.5 on the UPDRS total score. Amoderate CID was 4.5 to 6.7 points on the UPDRS motor score and 8.5 to 10.3 on the UPDRS total score. A large CID was 10.7 to 10.8 points on the UPDRS motor score and 16.4 to 17.8 on the UPDRS total score.Conclusions: Concordance among multiple approaches of analysis based on subjective and objective data show that reasonable estimates for the CID on the UPDRS motor score are 2.5 points for minimal, 5.2 for moderate, and 10.8 for large CIDs. Estimates for the UPDRS total score are 4.3 points for minimal, 9.1 for moderate, and 17.1 for large CIDs. These estimates will assist in determining clinically meaningful changes in PD progression and response to therapeutic interventions.