p53: 25 years after its discovery
p53: 25 years after its discovery
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DOI：
10.1016/j.tips.2004.02.009
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发表时间：
2004-04-01
影响因子：
13.8
通讯作者：
Harris, CC
中科院分区：
文献类型：
--
作者：
Hofseth, LJ;Hussain, SP;Harris, CC
自25年前发现以来，p53蛋白已成为细胞应激反应途径十字路口的关键肿瘤抑制蛋白。通过这些可以导致细胞周期停滞、DNA修复、细胞衰老、分化和凋亡的途径，p53促进受损细胞的修复和存活，或从复制池中消除严重受损的细胞以保护生物体。由于p53的这些动态和多种功能，这些功能在编码p53的基因突变后大部分丧失，因此该分子继续在生物医学研究中被深入研究，包括毒理学和药理学领域。在这篇文章中，我们简要回顾了前25年的研究p53。
Since its discovery 25 years ago, the p53 protein has emerged as a key tumor suppressor protein at the crossroads of cellular stress response pathways. Through these pathways, which can lead to cell-cycle arrest, DNA repair, cellular senescence, differentiation and apoptosis, p53 facilitates the repair and survival of damaged cells or eliminates severely damaged cells from the replicative pool to protect the organism. Because of these dynamic and multiple functions of p53, which are largely lost following mutations in the gene encoding p53, this molecule continues to be studied intensively in biomedical research, including the fields of toxicology and pharmacology. In this article, we briefly review the first 25 years of research on p53.