Volatiles from the ascomycete Daldinia cf. childiae (Hypoxylaceae), originating from China.
Volatiles from the ascomycete Daldinia cf. childiae (Hypoxylaceae), originating from China.
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DOI：
10.1039/c9md00083f
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发表时间：
2019-05
期刊：
影响因子：
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通讯作者：
Lukas Lauterbach;Tao Wang;M. Stadler;Jeroen S. Dickschat
中科院分区：
文献类型：
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作者：
Lukas Lauterbach;Tao Wang;M. Stadler;Jeroen S. Dickschat
本文采用闭环汽提仪对中国产的一种真菌Daldinia cfc . childiae的挥发物进行了分离，并采用气相色谱-质谱法进行了分析。通过质谱与文库谱和保留指数与文献表列数据的比较，对33个不同类别的化合物进行了严格的鉴定。对于未知的化合物，通过质谱推测其结构，并通过对照物质的化学合成进行验证。通过这种方法鉴定了两个2-烷基化呋喃衍生物，表明Daldinia属仍然是发现新的次生代谢物的有趣来源。以（1,2- 13c2）乙酸钠为原料，研究了聚酮5-羟基-2-甲基-4-铬罗曼酮的生物合成，有利于非酶环化步骤。
The volatiles from an isolate of the fungus Daldinia cf. childiae, obtained from a specimen collected in China, were collected by use of a closed-loop stripping apparatus and analysed by GC-MS. A total number of 33 compounds from different classes were rigorously identified by comparison of mass spectra to library spectra and of retention indices to tabulated data from the literature. For unknown compounds structural suggestions were delineated from the mass spectra and verified by chemical synthesis of reference materials. Through this approach two 2-alkylated furan derivatives were identified, demonstrating that the genus Daldinia continues to be an interesting source for the discovery of novel secondary metabolites. Feeding experiments with sodium (1,2-13C2)acetate were performed to investigate the biosynthesis of the polyketide 5-hydroxy-2-methyl-4-chromanone that are in favour of a non-enzymatic cyclisation step.