5-Sulfosalicylic acid catalyzed direct Mannich reaction in pure water
5-Sulfosalicylic acid catalyzed direct Mannich reaction in pure water
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DOI：
10.1016/j.molcata.2014.08.017
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发表时间：
2014-12
影响因子：
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通讯作者：
Cheng Chun;Zhu Xuyang;Ya Wu;Huaming Sun;Guofang Zhang;Wei‐qiang Zhang;Ziwei Gao
中科院分区：
文献类型：
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作者：
Cheng Chun;Zhu Xuyang;Ya Wu;Huaming Sun;Guofang Zhang;Wei‐qiang Zhang;Ziwei Gao
水溶性Brønsted酸5-磺基水杨酸在纯水中高效催化环己酮和3-戊酮的直接三组分Mannich反应。21个曼尼希反应的例子，提供了相应的β-氨基酮高达97%的收率和良好的非对映选择性。酸催化剂可以作为水溶液循环使用至少6次，曼尼希产品的收率保持在90%以上。
A water-soluble Brønsted acid, 5-sulfosalicylic acid, efficiently catalyzed the direct three-component Mannich reactions of cyclohexanone and 3-pentanone in pure water. 21 Examples of Mannich reactions were presented, which afforded the corresponding β-amino ketones with up to 97% yield and decent diastereoselectivities. The acid catalyst can be recycled as an aqueous solution for at least six times and the yield of the Mannich product remained over 90%.