Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders
Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders
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DOI：
10.1002/vms3.124
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发表时间：
2019-02-01
影响因子：
1.7
通讯作者：
Kaplan, Edward
中科院分区：
文献类型：
--
作者：
Hicks, Jill;Platt, Simon;Kaplan, Edward
Entotherapy 是一种图像引导的药物洗脱微柱平台，有可能绕过全身化疗在犬脑肿瘤治疗中的局限性。神经胶质瘤在狗中很常见，也是人类致命性脑肿瘤的大多数，可以接受替莫唑胺化疗。将与替莫唑胺和钆结合的生物聚合物微圆柱体植入四只客户拥有的患有神经胶质瘤的狗的部分切除肿瘤中。所有四只狗均出现全身性癫痫发作，并且在开颅手术时有轻度或无神经功能缺损。所有狗均接受开颅手术，将微圆柱体植入部分切除的神经胶质瘤（多形性胶质母细胞瘤{n = 1}或少突神经胶质瘤{n = 3}）。所有狗从开颅手术和植入手术中恢复良好。这种新颖的手术对于携带肿瘤的狗来说似乎是可行且耐受的。未来的对照临床研究现在可以旨在评估微圆柱体植入的长期疗效。
Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. All four dogs presented with generalized seizures and had mild to no neurologic deficits at the time of craniotomy. All dogs underwent craniotomy for implantation of the microcylinders into partially resected gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma {n = 3}). All dogs recovered well from the craniotomy and implantation procedure. This novel procedure appears to be feasible and tolerated in tumour-bearing dogs. A future controlled clinical study can now aim to evaluate the microcylinder implantation for long-term efficacy.