Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon.
Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon.
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无并发症疟疾期间的血清脂质和脂蛋白：加蓬兰巴雷内的一项队列研究。
DOI：
10.4269/ajtmh.16-0721
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
M. Grobusch
中科院分区：
文献类型：
--
作者：
B. J. Visser;S. G. de Vries;R. Vingerling;Martin Gritter;D. Kroon;Lídia Ciudad Aguilar;R. Kraan;R. W. Wieten;F. Danion;B. Sjouke;A. Adegnika;S. Agnandji;P. Kremsner;T. Hänscheid;P. Mens;M. van Vugt;M. Grobusch
摘要 已发现疟疾患者的血脂谱与健康对照者不同。我们研究了疟疾患者与其他发热性疾病患者的血清脂质谱随时间的变化。该研究总共纳入了 217 名患者（111 名疟疾患者和 106 名有症状对照者，定义为疟疾阴性发热患者）。与其他发热性疾病患者相比，疟疾患者的血清脂质水平（mmol/L）显着降低（总胆固醇[TC] = 3.26 [标准差= 0.94] vs 3.97 [1.22；P < 0.001]；高密度脂蛋白胆固醇[HDL-C] = 0.43 [0.47] vs 1.05 [0.67；P < 0.001]，疟疾患者的低密度脂蛋白胆固醇 [LDL-C] = 2.05 [0.76] 与 2.42 [0.90；P < 0.001] 相比，甘油三酯 (TG) 水平较高（1.81 [1.02] 与 1.11 [0.82；P < 0.001]）。第 28 天，胆固醇水平增加至参考值（TC = 3.26-3.98，P < 0.001；HDL-C = 0.43-0.96，P < 0.001；LDL-C = 2.05-2.60，P < 0.001）。TG 水平从入院时的 1.81 降至 1.76（第 3 天）。和 0.88（第 28 天；P = 0.130）。 脂质谱变化与寄生虫血症或恶性疟原虫富含组氨酸的蛋白 2 水平无关。这项研究证实了疟疾中特征性的暂时脂质谱变化。脂质谱变化证明了区分疟疾和其他发热性疾病的良好准确性（曲线下面积 = 0.80（95% 置信区间 =）。 0.742-0.863，P < 0.001）。关于疟疾脂质谱变化的病理生理学，存在一些合理的假设，以阐明精确的途径可能会提高对潜在病理生理学的理解。
AbstractThe serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol [TC] = 3.26 [standard deviation = 0.94] versus 3.97 [1.22; P < 0.001]; high-density lipoprotein cholesterol [HDL-C] = 0.43 [0.47] versus 1.05 [0.67; P < 0.001], low-density lipoprotein cholesterol [LDL-C] = 2.05 [0.76] versus 2.42 [0.90; P < 0.001]. Triglycerides (TGs) levels were higher in malaria patients (1.81 [1.02] versus 1.11 [0.82; P < 0.001]). No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 (TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology.
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影响因子：
6.5
作者：
K. Feingold;Ingibjorg Hardardottir;R. Memon;Eveline J. T. Krul;Arthur H. Maser;John M. Taylor;Carl Grunfeld
通讯作者：
K. Feingold;Ingibjorg Hardardottir;R. Memon;Eveline J. T. Krul;Arthur H. Maser;John M. Taylor;Carl Grunfeld
巨细胞病毒感染、脂蛋白(a) 和高凝状态：致动脉粥样硬化的联系？
DOI：
10.1161/01.atv.17.9.1780
发表时间：
1997
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Nieto,FJ;Sorlie,P;Comstock,GW;Wu,K;Adam,E;Melnick,JL;Szklo,M
通讯作者：
Szklo,M
DOI：
10.1016/s0021-9258(18)81794-x
发表时间：
1989-06
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
B. J. Auerbach;J. Parks
通讯作者：
B. J. Auerbach;J. Parks
使用国际临床化学和实验医学联合会提出的参考材料来评估血浆脂蛋白(a)测定的分析方法。
影响因子：
9.3
作者：
Marcovina,SM;Albers,JJ;Scanu,AM;Kennedy,H;Giaculli,F;Berg,K;Couderc,R;Dati,F;Rifai,N;Sakurabayashi,I;Tate,JR;Steinmetz,A
通讯作者：
Steinmetz,A
影响因子：
5.8
作者：
Anuurad, Erdembileg;Rubin, Jill;Berglund, Lars
通讯作者：
Berglund, Lars