Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
复制标题
细胞死亡的基本与附件方面：NCCD 2015的建议。
DOI：
10.1038/cdd.2014.137
复制
发表时间：
2015-01
影响因子：
12.4
通讯作者：
中科院分区：
文献类型：
--
作者：
细胞暴露在极端的物理化学或机械刺激下，由于其结构立即崩溃，以一种无法控制的方式死亡。这种不可避免的细胞死亡变体通常被称为“意外细胞死亡”（ACD）。然而，在大多数情况下，细胞死亡是由遗传编码装置引发的，这与药物或遗传干预可以改变其过程有关。“调节性细胞死亡”（RCD）可以作为生理程序的一部分发生，也可以在对细胞外或细胞内微环境扰动的适应性反应失败时被激活。可以利用伴随RCD的生化现象将其分为几个亚型，这些亚型通常（但不总是）表现出刻板的形态特征。然而，有效抑制通常被认为导致RCD的过程，如凋亡过程中刽子手半胱天酶的激活，并不能在哺乳动物系统中发挥真正的细胞保护作用，而只是改变细胞死亡的动力学，因为它改变了其形态和生化相关因素。相反，真正的细胞保护可以通过在该过程的早期阶段抑制致死信号的转导来实现，此时适应性反应仍在运行。因此，真正执行RCD的机制可能比以前认为的更不容易理解，更不容易抑制，可能更同质。在这里，细胞死亡命名委员会制定了一套建议，以帮助科学家和研究人员区分细胞死亡的基本和辅助方面。
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death' (ACD). In most settings, however, cell death is initiated by a genetically encoded apparatus, correlating with the fact that its course can be altered by pharmacologic or genetic interventions. ‘Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail. The biochemical phenomena that accompany RCD may be harnessed to classify it into a few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting the processes that are commonly thought to cause RCD, such as the activation of executioner caspases in the course of apoptosis, does not exert true cytoprotective effects in the mammalian system, but simply alters the kinetics of cellular demise as it shifts its morphologic and biochemical correlates. Conversely, bona fide cytoprotection can be achieved by inhibiting the transduction of lethal signals in the early phases of the process, when adaptive responses are still operational. Thus, the mechanisms that truly execute RCD may be less understood, less inhibitable and perhaps more homogeneous than previously thought. Here, the Nomenclature Committee on Cell Death formulates a set of recommendations to help scientists and researchers to discriminate between essential and accessory aspects of cell death.
登录
查看更多内容
影响因子：
4.3
作者：
Bonora, Massimo;Bononi, Angela;Pinton, Paolo
通讯作者：
Pinton, Paolo
影响因子：
9.8
作者：
Albeck JG;Burke JM;Spencer SL;Lauffenburger DA;Sorger PK
通讯作者：
Sorger PK
影响因子：
16
作者：
Bertrand, Mathieu J. M.;Milutinovic, Snezana;Barker, Philip A.
通讯作者：
Barker, Philip A.
影响因子：
16.2
作者：
ANKARCRONA, M;DYPBUKT, JM;NICOTERA, P
通讯作者：
NICOTERA, P
DOI：
10.1073/pnas.1401591111
发表时间：
2014-07-22
影响因子：
11.1
作者：
Alavian, Kambiz N.;Beutner, Gisela;Jonas, Elizabeth A.
通讯作者：
Jonas, Elizabeth A.