Double arylation of allyl alcohol via a one-pot Heck arylation-isomerization-acylation cascade.
Double arylation of allyl alcohol via a one-pot Heck arylation-isomerization-acylation cascade.
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DOI：
10.1021/ol202144z
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发表时间：
2011-09
期刊：
影响因子：
5.2
通讯作者：
P. Colbon;J. Ruan;M. Purdie;K. Mulholland;Jianliang Xiao
中科院分区：
文献类型：
--
作者：
P. Colbon;J. Ruan;M. Purdie;K. Mulholland;Jianliang Xiao
开发了一锅两步催化方案。芳基溴化物和烯丙醇之间的区域选择性Heck偶联导致芳基烯丙醇的生成，这些芳基烯丙醇在原位异构化得到醛，然后与第二个芳基溴进行酰化反应。在初始的Heck反应和酰化反应中都可以使用多种芳基溴化物，从而可以很容易地获得各种取代的二氢查尔酮。
A one-pot, two-step catalytic protocol has been developed. A regioselective Heck coupling between aryl bromides and allyl alcohol leads to the generation of arylated allyl alcohols that in situ isomerize to give aldehydes, which then undergo an acylation reaction with a second aryl bromide. A variety of aryl bromides can be employed in both the initial Heck reaction and the acylation, providing easy access to a wide variety of substituted dihydrochalcones.