The Parallel Auditory Brainstem Response
The Parallel Auditory Brainstem Response
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DOI：
10.1177/2331216519871395
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发表时间：
2019-09-01
影响因子：
2.7
通讯作者：
Maddox, Ross K.
中科院分区：
文献类型：
--
作者：
Polonenko, Melissa J.;Maddox, Ross K.
频率特异性纯音诱发听觉脑干反应（ABR）是听力学临床和实验室研究中不可缺少的工具。最常见的是，短纯音ABR用于评估婴儿、幼儿和其他无法进行行为测试的患者的听力阈值。因此，ABR检查的结果构成了关于干预和听力障碍的决定的基础，其影响深远到孩子的未来。目前，反应是由一次连续地呈现给一只耳朵的短纯音刺激的周期性序列引起的，这需要很长时间来测量多个频率和强度，并且如果婴儿醒得早，则提供不完整的信息。在这里，我们描述了一种新的方法，并行ABR（pABR），它使用随机定时的短纯音刺激，同时获得ABR波形在两个耳朵的五个频率。在这里，我们描述了pABR和量化其有效性，在解决目前的方法的最大缺点：测试时间。我们发现，在听力正常的成年人中，pABR在一定的强度范围内产生高质量的波形，在记录时间的一小部分中具有与标准ABR相似的形态。此外，较长的潜伏期和较小的振幅，在高强度的pABR与串行ABR诱发的低频率表明，反应可能有更好的位置特异性，由于其他同步短纯音序列提供的掩蔽。因此，pABR具有促进更快积累更多诊断信息的巨大潜力，这些信息对于及时识别和治疗听力损失非常重要。
The frequency-specific tone-evoked auditory brainstem response (ABR) is an indispensable tool in both the audiology clinic and research laboratory. Most frequently, the toneburst ABR is used to estimate hearing thresholds in infants, toddlers, and other patients for whom behavioral testing is not feasible. Therefore, results of the ABR exam form the basis for decisions regarding interventions and hearing habilitation with implications extending far into the child's future. Currently, responses are elicited by periodic sequences of toneburst stimuli presented serially to one ear at a time, which take a long time to measure multiple frequencies and intensities, and provide incomplete information if the infant wakes up early. Here, we describe a new method, the parallel ABR (pABR), which uses randomly timed toneburst stimuli to simultaneously acquire ABR waveforms to five frequencies in both ears. Here, we describe the pABR and quantify its effectiveness in addressing the greatest drawback of current methods: test duration. We show that in adults with normal hearing the pABR yields high-quality waveforms over a range of intensities, with similar morphology to the standard ABR in a fraction of the recording time. Furthermore, longer latencies and smaller amplitudes for low frequencies at a high intensity evoked by the pABR versus serial ABR suggest that responses may have better place specificity due to the masking provided by the other simultaneous toneburst sequences. Thus, the pABR has substantial potential for facilitating faster accumulation of more diagnostic information that is important for timely identification and treatment of hearing loss.