Why is the neurobiology of nausea and vomiting so important?
Why is the neurobiology of nausea and vomiting so important?
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DOI：
10.1016/j.appet.2007.09.015
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发表时间：
2008-03-01
期刊：
影响因子：
5.4
通讯作者：
Horn, Charles C.
中科院分区：
文献类型：
--
作者：
Horn, Charles C.
恶心和呕吐是引起药物副作用、疾病并存和预防食物中毒的重要生物系统。呕吐可以起到排空肠道中有毒化学物质的作用，而恶心似乎在避免摄入有害物质的条件性反应中发挥了作用。恶心和呕吐的感觉通路，如肠道和前庭输入，通常是被定义的，但确定大脑最终共同通路和恶心和呕吐的中枢模式生成器的问题在很大程度上还没有解决。对大脑通路的神经生理学分析提供了一个机会，可以更近距离地确定恶心、呕吐及其前驱症状(如冷汗、流口水)的神经生物学。(C)2007爱思唯尔有限公司。保留所有权利。
Nausea and vomiting are important as biological systems for drug side effects, disease co-morbidities, and defenses against food poisoning. vomiting can serve the function of emptying a noxious chemical from the gut, and nausea appears to play a role in a conditioned response to avoid ingestion of offending substances. The sensory pathways for nausea and vomiting, such as gut and vestibular inputs, are generally defined but the problem of determining the brain's final common pathway and central pattern generator for nausea and vomiting is largely unsolved. A neurophysiological analysis of brain pathways provides an opportunity to more closely determine the neurobiology of nausea and vomiting and its prodromal signs (e.g., cold sweating, salivation). (c) 2007 Elsevier Ltd. All rights reserved.