The bone marrow niche components are adversely affected in sepsis.
The bone marrow niche components are adversely affected in sepsis.
复制标题
骨髓小众成分在败血症中受到不利影响。
DOI：
10.1186/s43556-020-00010-3
复制
发表时间：
2020-10-20
影响因子：
4
通讯作者：
Ning B
中科院分区：
文献类型：
--
作者：
Yin F;Qian H;Duan C;Ning B
多器官功能障碍是脓毒症患者死亡的重要原因。目前，很少有研究集中在脓毒症对骨髓（BM）的影响，特别是对BM生态位的细胞成分。本研究通过腹腔注射LPS和盲肠结扎穿孔（CLP）建立小鼠脓毒症模型。观察并分析小鼠骨髓中血管结构、间充质干细胞和调节性T细胞之间的生态位主要成分的变化。结果显示，BM的病理改变较其他器官早且明显，BM生态位的各种细胞成分发生明显变化，其中血管内皮细胞一过性增多，血管重塑，调节性T细胞长期减少。这些结果表明，在脓毒症的BM生态位的成分经历了一系列的适应性变化。
Multiple organ dysfunction is an important cause of death in patients with sepsis. Currently, few studies have focused on the impact of sepsis on bone marrow (BM), especially on the cell components of BM niche. In this study, we performed mouse sepsis models by intraperitoneal injection of LPS and cecal ligation and puncture (CLP). The changes of niche major components in the mouse BM among vascular structures, mesenchymal stem cells and Treg cells were observed and analyzed. The results showed that pathological changes in BM was earlier and more prominent than in other organs, and various cell components of the BM niche changed significantly, of which vascular endothelial cells increased transiently with vascular remodeling and the regulatory T cells decreased over a long period of time. These results indicated that the components of the BM niche underwent series of adaptive changes in sepsis.