Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma
Association of T-cell regulatory gene polymorphisms with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma
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DOI：
10.1200/jco.2005.05.5434
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发表时间：
2006-07-20
影响因子：
45.3
通讯作者：
Wu, Ming-Shiang
中科院分区：
文献类型：
--
作者：
Cheng, Tsu-Yao;Lin, Jaw-Town;Wu, Ming-Shiang
目的幽门螺杆菌（Helicobacter pylori，Hp）感染与宿主易感性相互作用，导致胃粘膜相关淋巴组织（MALT）淋巴瘤的发生，特异性T细胞的激活在此过程中可能起着重要作用。最近的研究表明，CTLA 4，CD 28和ICOS基因位于染色体2 q33上，它们的多态性通过T细胞刺激的失调而赋予对感染性和免疫性疾病的易感性。我们的目的是确定CTLA 4、CD 28和ICOS多态性在胃MALT淋巴瘤中的作用。（49 A/G、-318 C/T和CT60 A/G），CD28（IVS3+ 17 T/C），和ICOS（c.602 A/C和c.1624C/T）对62例胃MALT淋巴瘤患者进行H pylon感染检测，并与250例健康对照组进行比较。胃MALT淋巴瘤组（90.3%）与对照组（66.4%; P
PurposeHelicobacter pylori infection and host susceptibility interact to develop gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and activation of specific T cells might play a crucial role in this process. Recent investigations show that the CTLA4, CD28, and ICOS genes are located on chromosome 2q33 and their polymorphisms confer susceptibility to infectious and immune diseases through deregulation of T-cell stimulation. We aimed to determine the role of CTLA4, CD28, and ICOS polymorphisms in gastric MALT lymphoma.Patients and MethodsGenotyping for CTLA4 (49 A/G, -318 C/T, and CT60 A/G), CD28 (IVS3+ 17T/C), and ICOS (c.602 A/C and c.1624C/T) was performed for 62 patients with gastric MALT lymphoma and compared with 250 unrelated healthy controls.ResultsH pylon infection was significantly higher in patients with gastric MALT lymphoma (90.3%) compared with controls (66.4%; P