Molecular Imaging in the Second Near-Infrared Window
Molecular Imaging in the Second Near-Infrared Window
复制标题
DOI：
10.1002/adfm.201900566
复制
发表时间：
2019-06-01
影响因子：
19
通讯作者：
Dai, Hongjie
中科院分区：
文献类型：
--
作者：
Wan, Hao;Du, Haotian;Dai, Hongjie
近十年来，在第二近红外（NIR-II）窗口的荧光成像方面取得了显著进展。NIR-II窗口的荧光成像具有穿透深层组织和高时空分辨率的优势，有利于生理过程的分析。与此同时，分子成像已经成为在分子和细胞水平上破译生物活动的有效工具。将分子成像扩展到NIR-II窗口将提高成像性能，提供更详细和准确的生物系统信息。在本进展报告中，对NIR-II分子成像的部分成果进行了综述。本报告的组织是基于NIR-II成像探针合理设计的策略，并强调了它们在分子成像中的应用。该进展报告可为进一步开发高性能分子成像功能NIR-II探针提供指导和参考。
In the past decade, noticeable progress has been achieved regarding fluorescence imaging in the second near-infrared (NIR-II) window. Fluorescence imaging in the NIR-II window demonstrates superiorities of deep tissue penetration and high spatial and temporal resolution, which are beneficial for profiling physiological processes. Meanwhile, molecular imaging has emerged as an efficient tool to decipher biological activities on the molecular and cellular level. Extending molecular imaging into the NIR-II window would enhance the imaging performance, providing more detailed and accurate information of the biological system. In this progress report, selected achievements made in NIR-II molecular imaging are summarized. The organization of this report is based on strategies underlying rational designs of NIR-II imaging probes, and their applications in molecular imaging are highlighted. This progress report may provide guidance and reference for further development of functional NIR-II probes designed for high-performance molecular imaging.