STRUCTURE OF THE SEGMENTATION GENE PAIRED AND THE DROSOPHILA PRD GENE SET AS PART OF A GENE NETWORK
STRUCTURE OF THE SEGMENTATION GENE PAIRED AND THE DROSOPHILA PRD GENE SET AS PART OF A GENE NETWORK
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DOI：
10.1016/0092-8674(86)90516-7
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发表时间：
1986-12-05
期刊：
影响因子：
64.5
通讯作者：
NOLL, M
中科院分区：
文献类型：
--
作者：
FRIGERIO, G;BURRI, M;NOLL, M
本文报道了果蝇染色体分节所需的配对规则基因pairing的序列。搜索与配对基因同源的结构域的基因，并从一组12个同源物的特征在于相对于时间或空间表达和序列同源性。所有四种都在早期发育中转录，一种在卵母细胞中转录，并在卵裂阶段以梯度形式转录。除了prd特异性的his-pro重复序列外，12个基因中的一些还含有M-重复序列和两种新类型的homeo盒，这两种新类型的homeo盒通过与两种已知类型的homeo盒杂交而检测不到。所观察到的基因组通过编码蛋白质结构域的同源性组合的连接与基因作用的一般网络概念一致。
The sequence of paired, a pair-rule gene required for segmentation in Drosophila, is presented. A search for genes with domains homologous to the paired gene was initiated and three homologues from a set of 12 were characterized with respect to temporal or spatial expression and sequence homologies. All four are transcribed in early development, one in the oocyte and during cleavage stages in the form of a gradient. In addition to the prd-specific his-pro repeat, some of the 12 genes contain M-repeats and two new types of homeo boxes not detectable by hybridization with the two known classes of homeo boxes. The observed linking of gene sets through combinations of homologies coding for protein domains is consistent with a general network concept of gene action.