IRWRLDA: improved random walk with restart for lncRNA-disease association prediction.
IRWRLDA: improved random walk with restart for lncRNA-disease association prediction.
复制标题
IRWRLDA：改进随机游走并重新启动 lncRNA 疾病关联预测
DOI：
10.18632/oncotarget.11141
复制
发表时间：
2016-09-06
期刊：
影响因子：
--
通讯作者：
Gong DW
中科院分区：
文献类型：
--
作者：
Chen X;You ZH;Yan GY;Gong DW
近年来，越来越多的证据表明，lncrna的失调与广泛的人类疾病有关。分析已知的lncrna -疾病关联，预测潜在的lncrna -疾病关联，提供最可能的lncrna -疾病对进行实验验证，是必要和可行的。考虑到传统随机行走与重启（RWR）的局限性，通过整合已知的lncRNA-疾病关联、疾病语义相似度和各种lncRNA相似度度量，建立了改进的lncRNA-疾病关联预测随机行走与重启模型（IRWRLDA）来预测新的lncRNA-疾病关联。IRWRLDA的新颖之处在于结合lncRNA表达相似度和疾病语义相似度来设置RWR的初始概率向量。因此，IRWRLDA可以应用于没有任何已知相关lncrna的疾病。在从lncRNADisease数据库下载的两个已知lncrna -疾病关联数据集中，IRWRLDA显著改进了之前的经典模型，可靠auc分别为0.7242和0.7872。IRWRLDA在结肠癌和白血病的进一步病例研究中，最近的实验报告证实了前10位预测列表中60%的lncrna。
In recent years, accumulating evidences have shown that the dysregulations of lncRNAs are associated with a wide range of human diseases. It is necessary and feasible to analyze known lncRNA-disease associations, predict potential lncRNA-disease associations, and provide the most possible lncRNA-disease pairs for experimental validation. Considering the limitations of traditional Random Walk with Restart (RWR), the model of Improved Random Walk with Restart for LncRNA-Disease Association prediction (IRWRLDA) was developed to predict novel lncRNA-disease associations by integrating known lncRNA-disease associations, disease semantic similarity, and various lncRNA similarity measures. The novelty of IRWRLDA lies in the incorporation of lncRNA expression similarity and disease semantic similarity to set the initial probability vector of the RWR. Therefore, IRWRLDA could be applied to diseases without any known related lncRNAs. IRWRLDA significantly improved previous classical models with reliable AUCs of 0.7242 and 0.7872 in two known lncRNA-disease association datasets downloaded from the lncRNADisease database, respectively. Further case studies of colon cancer and leukemia were implemented for IRWRLDA and 60% of lncRNAs in the top 10 prediction lists have been confirmed by recent experimental reports.