Investigation of the prognostic value of adipokines in multiple sclerosis
Investigation of the prognostic value of adipokines in multiple sclerosis
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DOI：
10.1016/j.msard.2017.04.006
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发表时间：
2017-07-01
影响因子：
4
通讯作者：
Tamam, Yusuf
中科院分区：
文献类型：
--
作者：
Coban, Arzu;Duzel, Berna;Tamam, Yusuf
背景：脂肪因子可能参与多发性硬化（MS）以及其他炎症性疾病。本研究旨在分析血清脂肪因子水平作为判断MS临床进展的生物标志物的价值。方法：共招募了90名受试者，其中包括40名健康个体和50名MS患者[24名具有经典MS临床病程（C-MS），26名具有良性MS（B-MS）]。结果：C-MS患者血清脂联素、MCP-1、TNF-α和IL-6水平均显著高于B-MS患者和健康对照组。只有脂联素和MCP-1水平在Bonferroni校正后仍显着升高。脂联素、MCP-1和TNF-α水平与扩展残疾状态量表（EDSS）评分呈中度相关，Bonferroni校正后消失。结论：我们的研究结果表明脂肪因子在MS的发病机制和临床进展中的潜在作用。脂联素和MCP-1可能作为MS的预后生物标志物。
Background: Adipokines may be involved in multiple sclerosis (MS) as well as other inflammatory diseases. This study aimed to analyze the value of serum adipokine levels as biomarkers in determining the clinical progression of MS.Methods: A total of 90 subjects including 40 healthy individuals and 50 MS patients [24 with classical clinical course of MS (C-MS), 26 with benign MS (B-MS)] were recruited for this study. The levels of serum adipokines and inflammatory mediators were measured using immunoassay methods.Results: The levels of adiponectin, MCP-1, TNF-alpha and IL-6 were significantly higher in C-MS patients compared with B-MS patients and healthy controls. Only adiponectin and MCP-1 levels remained significantly high after Bonferroni correction. Adiponectin, MCP-1 and TNF-alpha levels showed a modest correlation with expanded disability status scale (EDSS) scores, which disappeared after Bonferroni correction.Conclusions: Our findings suggest the potential role of adipokines in pathogenesis and clinical progression of MS. Adiponectin and MCP-1 might potentially serve as prognostic biomarkers in MS.