POSTEXERCISE MUSCLE AND LIVER-GLYCOGEN METABOLISM IN MALE AND FEMALE RATS
POSTEXERCISE MUSCLE AND LIVER-GLYCOGEN METABOLISM IN MALE AND FEMALE RATS
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DOI：
10.1152/jappl.1987.62.3.1250
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发表时间：
1987-03-01
影响因子：
3.3
通讯作者：
GAESSER, GA
中科院分区：
文献类型：
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作者：
IVEY, PA;GAESSER, GA
雄性和雌性Wistar大鼠以17%的速度以1.7 mph的速度跑5 min，以确定在恢复过程中快缩红肌、快缩白色肌和肝脏的糖原再合成速率是否存在性别差异。在三个时间点之一处死大鼠：运动后立即，1或4小时后。男性静息肌糖原水平显著高于男性（P < 0.05）。运动导致男女大鼠糖原消耗显著（P < 0.01）。使用的雄性运动时糖原含量比女性高50%（P < 0.05）。在禁食4h恢复期内，肌糖原在恢复后1h内显著增加（P < 0.05）。肝糖原并没有因为运动而耗尽，而是在恢复的第一个小时内下降（P < 0.05），并在随后的3小时内保持低水平。男性在运动过程中红色和白色快缩肌的糖原利用率更高，这可能代表了真正的性别差异，但也可能部分归因于男性因体重增加20%而进行更多的工作。我们的结论是：1）运动后肌糖原补充率或运动中和运动后肝糖原代谢率无性别差异，2）运动后肌糖原快速补充发生在肝糖原加速消耗的时候。
Male and female Wistar rats were run for 5 min at 1.7 mph at a 17% grade to determine whether a sex difference exists in the rate of glycogen resynthesis during recovery in fast-twitch red muscle, fast-twitch white muscle, and liver. Rats were killed at one of three time points: immediately after the exercise bout, and at 1 or 4 h later. Males had significantly higher resting muscle glycogen levels (P < 0.05). Exercise resulted in significant glycogen depletion in both sexes (P < 0.01). Males utilized .apprx. 50% more glycogen during the exercise bout than females (P < 0.05). During the food-restricted 4-h recovery period, muscle glycogen was repleted significantly during the 1st h (P < 0.05). Liver glycogen was not depleted as a result of the exercise bout, but fell during the first h of recovery (P < 0.05) and remained low during the subsequent 3 h. The greater glycogen utilization in red and white fast-twitch muscle during exercise by males could represent a true sex difference but could also be attributable in part to the males having performed more work as a result of 20% greater body mass. We conclude that 1) no sex difference was observed in the rates of muscle glycogen repletion after exercise or in liver glycogen metabolism during and after exercise, and 2) rapid postexercise muscle glycogen repletion occurred at a time of accelerated liver glycogen depletion.