Propagation of interictal epileptiform activity can lead to erroneous source localizations: A 128-channel EEG mapping study
Propagation of interictal epileptiform activity can lead to erroneous source localizations: A 128-channel EEG mapping study
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DOI：
10.1097/00004691-200309000-00003
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发表时间：
2003-09-01
影响因子：
2.4
通讯作者：
Michel, CM
中科院分区：
文献类型：
--
作者：
Lantz, G;Spinelli, L;Michel, CM
发作间期癫痫样活动与致痫区之间的关系是复杂的。尽管事实上，可能会发生刺内传播，尖峰的峰值通常被用作发作发作部位的指标。在这项调查中，时空分割被用来证明这intraspike传播，并确定在哪个时间点的电压模式对应最好的致痫区。本文报道16例局灶性癫痫患者的125导脑电图。在尖峰的上升阶段，确定了一到五种不同的地图地形。使用分布源模型（EPIFOCUS）定位每个图的源，并计算EPIFOCUS最大值到解剖病变的距离。在16例病例中，只有3例病例的整个尖峰上升期由一个单一的图所占。在另外5名患者中，获得了几个地图，尽管所有的都位于致癫痫病变内。然而，在其余8例患者中，部分上升相位于致痫性病变之外。平均而言，80%的上升时间在病变部位内，最可靠的时间段是发病和峰值之间的一半。结果表明，intraspike传播必须考虑在源定位，他们也说明了有用的时空分割可视化这种传播。
The relationship between interictal epileptiform activity and the epileptogenic zone is complex. Despite the fact that intraspike propagation may occur, the peak of the spike is often used as indicator of the site of ictal onset. In this investigation, spatio-temporal segmentation was used to demonstrate this intraspike propagation and to determine at which time point the voltage pattern corresponded best to the epileptogenic zone. Sixteen patients with focal epilepsy were recorded with 125-channel EEG. Between one and five different map topographies were identified during the rising phase of the spike. A distributed source model (EPIFOCUS) was used to localize the source of each map, and the distance from the EPIFOCUS maximum to the anatomic lesion was calculated. In only 3 of 16 cases was the entire rising phase of the spike accounted for by one single map. In another five patients, several maps were obtained, although all were located within the epileptogenic lesion. In the remaining eight patients, however, parts of the rising phase had locations outside the epileptogenic lesion. On the average, 80% of the rising time had within lesion locations the most reliable time period being halfway between onset and peak. The results illustrate that intraspike propagation has to be considered in source localizations, and they also illustrate the usefulness of spatio-temporal segmentation for visualizing this propagation.