Family tracing to identify patients with Familial Hypercholesterolaemia: the Second Audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project
Family tracing to identify patients with Familial Hypercholesterolaemia: the Second Audit of the Department of Health Familial Hypercholesterolaemia Cascade Testing Project
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DOI：
10.1258/acb.2008.008094
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发表时间：
2009-01-01
影响因子：
2.2
通讯作者：
Humphries, S. E.
中科院分区：
文献类型：
--
作者：
Hadfield, S. G.;Horara, S.;Humphries, S. E.
背景：家族追踪是发现新的家族性高胆固醇血症 (FH) 患者的一种公认方法。我们实施了由 FH 护士领导的家庭追踪，并确定了患者的可接受性、可行性和成本。方法：在五个国家医疗服务 (NHS) 信托机构中找到了护士；他们识别出 FH 患者并为他们提供家人追踪服务。反应和测试结果记录在数据库中，并总结在家族谱系中。结果：大多数（大约 70%）指示病例参与了；当患者出院和在大都市地区时，这一比例较低。平均而言，34%（范围 13-50%）的亲属居住在诊所服务范围之外，无法前往护士主导的 FH 诊所就诊。在之前未接受检测的亲属中，有 76% 居住在该诊所的服务范围内，主动接受了检测。前来检测的亲属中有三分之一是儿童
Background: Family tracing is a method recognized to find new patients with familial hypercholesterolaemia (FH). We have implemented family tracing led by FH Nurses and have determined acceptability to patients, feasibility and costs.Methods: Nurses were located at five National Health Service (NHS) Trusts; they identified FH patients and offered them family tracing. Responses and test results were recorded on a database and summarized on a family pedigree.Results: The majority (similar to 70%) of index cases participated; the proportion was lower when patients had been discharged from the clinics and in metropolitan areas. On average, 34% (range 13-50%) of relatives lived outside the catchment area of the clinics and could not attend the nurse-led FH clinics. Of the previously untested relatives, 76% who lived in the catchment area of the clinic came forward to be tested. One-third of the relatives who came forward for testing were children