Daffodils as potential crops of galanthamine. Assessment of more than 100 ornamental varieties for their alkaloid content and acetylcholinesterase inhibitory activity
Daffodils as potential crops of galanthamine. Assessment of more than 100 ornamental varieties for their alkaloid content and acetylcholinesterase inhibitory activity
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DOI：
10.1016/j.indcrop.2012.07.034
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发表时间：
2013-05-01
影响因子：
5.9
通讯作者：
Bastida, Jaume
中科院分区：
文献类型：
--
作者：
Torras-Claveria, Laura;Berkov, Strahil;Bastida, Jaume
水仙的许多植物品种（石蒜科）被大规模种植用于观赏目的，但它们也已知含有加兰他敏，一种用于抗乙酰胆碱酯酶治疗阿尔茨海默病的生物活性生物碱。水仙的100多个观赏品种，分别使用叶子和鳞茎，的加兰他敏含量以及它们的乙酰胆碱酯酶抑制活性进行筛选，以寻找加兰他敏的新的潜在来源。加兰他敏在97个观赏品种的叶片或鳞茎中均有分布，其中水仙叶片中含量最高，占干重的0.46%，黄翅品种鳞茎中含量最高，占干重的0.14%。在22个观赏水仙品种的叶片和鳞茎中也发现了比加兰他敏更强的乙酰胆碱酯酶抑制剂血根碱，其乙酰胆碱酯酶抑制活性较高。(C)2012爱思唯尔有限公司版权所有。
Many plant varieties of Narcissus (Amaryllidaceae) are cultivated on a large scale for ornamental purposes but they are also known to contain galanthamine, a bioactive alkaloid used in antiacetylcholinesterasic therapy in Alzheimer's disease.More than 100 ornamental varieties of Narcissus, using leaves and bulbs separately, were screened for their galanthamine content as well as their acetylcholinesterase inhibitory activity in the search for new potential sources of galanthamine.GC-MS was used for the quantitative analysis of galanthamine, and the biological activity was determined by an acetylcholinesterase in vitro assay.Galanthamine was found to occur in the leaves or bulbs of 97 ornamental varieties, the maximal amount being 0.46% referred to DW in the leaves of Narcissus hispanicus, and 0.14% in the bulbs of the cultivar 'Yellow Wings'. Sanguinine, an even more powerful inhibitor of acetylcholinesterase than galanthamine, was also found in the leaves and bulbs of 22 ornamental varieties of Narcissus, which exhibited a high acetylcholinesterase inhibitory activity. (C) 2012 Elsevier B.V. All rights reserved.