Patterning of frontal cortex subdivisions by Fgf17
Patterning of frontal cortex subdivisions by Fgf17
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DOI：
10.1073/pnas.0702225104
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发表时间：
2007-05-01
影响因子：
11.1
通讯作者：
Rubenstein, John L. R.
中科院分区：
文献类型：
--
作者：
Cholfin, Jeremy A.;Rubenstein, John L. R.
额叶皮层（FC）是高级认知的所在地。控制FC功能不同亚类形成的遗传机制尚不清楚。使用一组区分新生小鼠FC的细分的基因表达标记，我们表明，FGF 17的损失选择性地减少背侧FC的大小，而腹侧/眶FC出现正常。这些变化是由感觉皮层区域的喙部移位补充的。因此，Fgf 17的功能类似于Fgf 8在图案化的整体新皮层地图，但具有更有选择性的作用，在调节背侧，而不是腹侧FC的属性。
The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.