Regulation of respiratory neuron development by neurotrophic and transcriptional signaling mechanisms
Regulation of respiratory neuron development by neurotrophic and transcriptional signaling mechanisms
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DOI：
10.1016/j.resp.2005.02.007
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发表时间：
2005-11-15
影响因子：
2.3
通讯作者：
Katz, DM
中科院分区：
文献类型：
--
作者：
Katz, DM
功能多样的呼吸神经元群体似乎是常见神经营养和转录信号通路的目标。例如，桥脑 A5 细胞群中的外周化学传入神经元和去甲肾上腺素能神经元都需要脑源性神经营养因子 (BDNF) 和神经胶质细胞系源性神经营养因子 (GDNF) 的共同信号传导才能生存、生长和/或表型分化。此外，这些相同的细胞群依赖于转录因子 Phox2 家族来进行早期细胞类型规范。此外，BDNF 及其受体 TrkB 在呼吸节律产生的关键部位 preBotzinger 复合体 (pBC) 中表达，外源性 BDNF 可以调节 pBC 神经元的活性。 BDNF、GDNF 和 Phox2 依赖性的这种融合可能有助于解释这些途径中的突变如何导致人类呼吸发育障碍。 (c) 2005 Elsevier B.V. 保留所有权利。
Functionally diverse populations of respiratory neurons appear to be targets of common neurotrophic and transcriptional signaling pathways. For example, peripheral chemoafferent neurons and noradrenergic neurons in the pontine A5 cell group both require co-signaling by brain derived neurotrophic factor (BDNF) and glial cell line derived neurotrophic factor (GDNF) for survival, growth and/or phenotypic differentiation. Moreover, these same cell groups are dependent on the Phox2 family of transcription factors for early cell type specification. In addition, BDNF and its receptor, TrkB, are expressed in the preBotzinger complex (pBC), a critical site for respiratory rhythm generation, and exogenous BDNF can modulate the activity of pBC neurons. This convergence of BDNF, GDNF and Phox2 dependencies may help to explain how mutations in each of these pathways can result in human developmental disorders of breathing. (c) 2005 Elsevier B.V. All rights reserved.