Evaluating the progenitor cells of ovarian cancer: analysis of current animal models.
Evaluating the progenitor cells of ovarian cancer: analysis of current animal models.
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DOI：
10.5483/bmbrep.2011.44.7.435
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发表时间：
2011-07
期刊：
影响因子：
3.8
通讯作者：
Burdette JE
中科院分区：
文献类型：
--
作者：
King SM;Burdette JE
浆液性卵巢癌是妇科恶性肿瘤中最致命的一种。这种疾病的有效诊断和治疗方法的进展受到这种组织型卵巢癌的细胞起源不明确以及有限的合适动物模型来分析疾病早期阶段的阻碍。在这份报告中，我们将审查目前的动物模型方面提出的两个祖细胞浆液性卵巢癌，卵巢表面上皮和输卵管上皮。
Serous ovarian cancer is one of the most lethal gynecological malignancies. Progress on effective diagnostics and therapeutics for this disease are hampered by ambiguity as to the cellular origins of this histotype of ovarian cancer, as well as limited suitable animal models to analyze early stages of disease. In this report, we will review current animal models with respect to the two proposed progenitor cells for serous ovarian cancer, the ovarian surface epithelium and the fallopian tube epithelium.