G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions
G-quadruplex DNA and RNA: Their roles in regulation of DNA replication and other biological functions
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DOI：
10.1016/j.bbrc.2020.05.132
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发表时间：
2020-10-08
影响因子：
3.1
通讯作者：
Tanaka, Taku
中科院分区：
文献类型：
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作者：
Masai, Hisao;Tanaka, Taku
G-四链体是研究最深入的非 B 型 DNA 之一，目前已知它普遍存在于几乎所有生物物种的基因组中。最近的研究揭示了 G 四链体 (G4) 结构在各种核酸和染色体交易中的作用。在这篇短文中，我们将首先描述 G4 在 DNA 复制调节中的作用的最新发现。 G4 通过与特定结合蛋白 Rif1 相互作用，参与 DNA 复制的时空调节。这种调节至少部分是通过 Rif1-G4 相互作用产生特定染色质结构来介导的。我们还将描述最近的研究，这些研究表明 G4 在 DNA 复制起始中的潜在作用。接下来，我们将展示 DNA G4 和 RNA G4 在核酸和染色体功能调节中的高度多样化的作用。最后，我们将讨论如何调节细胞 G4 的形成。 (C) 2020 Elsevier Inc. 保留所有权利。
G-quadruplex is one of the best-studied non-B type DNA that is now known to be prevalently present in the genomes of almost all the biological species. Recent studies reveal roles of G-quadruplex (G4) structures in various nucleic acids and chromosome transactions. In this short article, we will first describe recent findings on the roles of G4 in regulation of DNA replication. G4 is involved in regulation of spatio-temporal regulation of DNA replication through interaction with a specific binding protein, Rif1. This regulation is at least partially mediated by generation of specific chromatin architecture through Rif1-G4 interactions. We will also describe recent studies showing the potential roles of G4 in initiation of DNA replication. Next, we will present showcases of highly diversified roles of DNA G4 and RNA G4 in regulation of nucleic acid and chromosome functions. Finally, we will discuss how the formation of cellular G4 could be regulated. (C) 2020 Elsevier Inc. All rights reserved.