Epilepsy and migraine: The dopamine hypotheses
Epilepsy and migraine: The dopamine hypotheses
复制标题
DOI：
10.1016/j.mehy.2005.09.045
复制
发表时间：
2006-01-01
影响因子：
4.7
通讯作者：
Chen, SC
中科院分区：
文献类型：
--
作者：
Chen, SC
偏头痛和癫痫都是阵发性发作的慢性复发性疾病。他们还具有一些相似的危险因素、症状和预防药物。长期以来，许多支持证据都认为多巴胺与偏头痛和癫痫发生的病理生理学有关。然而，多巴胺的作用至今仍存在争议。采用综合假设模型可能是原因之一。 “多巴胺假说”并不是一个新术语，但提出它是为了解释这些疾病的病理生理学和相关现象。这些假设表明，在偏头痛中，多巴胺处于低状态，而在全身性癫痫中，多巴胺处于高状态。但头痛和癫痫发作的周期性发作可能都是由于多巴胺活性下降所致。因此，多巴胺在神经内分泌、自主系统和神经元活动的联系中起着关键作用。多巴胺激动剂也可用于这两种疾病的预防和神经保护。 (c) 2005 Elsevier Ltd. 保留所有权利。
Migraine and epilepsy are both chronic recurrent disorders with paroxysmal attacks. They also share some similar risk factors, symptoms, and preventive medications. Dopamine has long been postulated to be involved in the pathophysiology of migraine and epileptogenesis, by many supporting evidences. However, the role of dopamine is still controversial till now. A tack of a comprehensive hypothetical model may be one of the reasons. "Dopamine hypothesis" is not a new term, but it is proposed to explain the pathophysiology and the associated phenomena of these disorders. The hypotheses suggest that, in migraine, there is a low dopamine tone, white there is a high state of dopamine in generalized epilepsy. But the periodic attacks of headaches and seizures maybe both due to a fall in dopamine activity. Dopamine therefore plays a key rote in the linkage of neuroendocrine, autonomic system and neuronal activity. Dopamine agonist is also implied in prophylaxis and neuroprotection in both disorders. (c) 2005 Elsevier Ltd. All rights reserved.