DIFFERENTIAL-EFFECTS OF METHYLPHENIDATE AND DEXTROAMPHETAMINE ON THE MOTOR-ACTIVITY LEVEL OF HYPERACTIVE-CHILDREN
DIFFERENTIAL-EFFECTS OF METHYLPHENIDATE AND DEXTROAMPHETAMINE ON THE MOTOR-ACTIVITY LEVEL OF HYPERACTIVE-CHILDREN
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DOI：
10.1016/0893-133x(89)90029-8
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发表时间：
1989-12-01
影响因子：
7.6
通讯作者：
RAPOPORT, JL
中科院分区：
文献类型：
--
作者：
BORCHERDING, BG;KEYSOR, CS;RAPOPORT, JL
在日间医院项目中，使用加速度敏感装置连续测量 18 名多动男孩全天的运动活动。在一项为期 11 周的双盲交叉试验中，孩子们每天早餐和午餐后服用哌醋甲酯、右旋苯丙胺或安慰剂。发现这两种药物在降低运动活动方面的效果不同。哌醋甲酯显着降低了上午结构化课堂和下午结构化活动的活动测量值。在我们的课堂环境中，上午 11:00 至中午，右旋苯丙胺对活动的影响相似，但与安慰剂的影响没有显着差异。在上午 11:00 至下午 1:00 之间，哌醋甲酯对运动活动的影响比右旋苯丙胺更大。在所使用的剂量范围内，每个药物阶段内的药物剂量之间的活性水平没有显着差异（哌醋甲酯 0.45 至 1.25 mg/kg，每天两次，右旋苯丙胺 0.2 至 0.6 mg/kg，每天两次）。血浆药物浓度与这两种药物的活性降低无关。
An acceleration-sensitive device was used to measure motor activity continuously through the day in 18 hyperactive boys in a day hospital program. The children received methylphenidate, dextroamphetamine, or placebo daily after breakfast and lunch in an 11-week double-blind crossover trial. Differential effectiveness of the two drugs in lowering motor activity was found. Methylphenidate significantly lowered activity measurements in a morning structured classroom and in less structured activities in the afternoon. Dextroamphetamine effects on activity were similar, although they did not differ significantly from placebo effects between 11:00 AM and noon in our classroom setting. Methylphenidate produced a greater decrement in motor activity than did dextroamphetamine between 11:00 AM and 1:00 PM. There were no significant differences in activity level between drug doses within each drug phase across the dose ranges used (for methylphenidate 0.45 to 1.25 mg/kg given twice daily, and for dextroamphetamine 0.2 to 0.6 mg/kg given twice daily). Plasma drug concentrations did not correlate with decrements in activity for either drug.