SATB2 is a supplementary immunohistochemical marker to CDX2 in the diagnosis of colorectal carcinoma metastasis in an unknown primary
SATB2 is a supplementary immunohistochemical marker to CDX2 in the diagnosis of colorectal carcinoma metastasis in an unknown primary
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DOI：
10.1111/apm.12854
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发表时间：
2018-06-01
期刊：
影响因子：
2.8
通讯作者：
Christiansen, Jens Johannes
中科院分区：
文献类型：
--
作者：
Dabir, Parag Deepak;Svanholm, Hans;Christiansen, Jens Johannes
CDX 2通常用于识别转移性腺癌的胃肠道起源;但高百分比的其他癌也显示出该抗体的阳性。SATB 2是一种新的免疫组织化学标记物，一些研究表明它在大多数结直肠腺癌中特异性表达。为了确定原发部位是否可以被鉴定为“结肠-直肠”，我们评估了具有转移的患者材料中的SATB 2沿着CDX 2。回顾性分析67例肝活检标本、108例淋巴结切除标本和36例浆膜腔积液的转移情况。由两名病理学家分别评估CDX 2和SATB 2染色的盲态载玻片，并计算灵敏度、特异性和kappa统计量。CDX 2在结直肠腺癌转移中的敏感性为93%，而SATB 2为79%。CDX 2和SATB 2联合检测的敏感性为79%，特异性为93%。在结直肠腺癌转移的情况下，病理学家对两种标志物的一致性水平（=0.64）可接受。与SATB 2相比，CDX 2是一种敏感的标志物;而CDX 2和SATB 2的组合对于结直肠腺癌的转移的特异性高。SATB 2可与CDX 2一起沿着用作补充标记物，以鉴定从临床表现为转移的患者接收的材料的结肠直肠来源。
CDX2 is routinely used for identifying gastrointestinal origin of metastatic adenocarcinomas; but a high percentage of other carcinomas also show positivity with this antibody. SATB2 is a new immunohistochemical marker with a few studies showing that it is specifically expressed in a large majority of colorectal adenocarcinomas. We assessed SATB2 along with CDX2 in patient material with metastasis in order to determine whether the primary site could be identified as colon-rectum'. Metastasis in 67 liver biopsies, 108 lymph nodes from resection specimens and 36 serous effusions was analyzed retrospectively. Blinded slides stained for CDX2 and SATB2 were assessed individually by two pathologists and sensitivity, specificity and kappa statistics were calculated. Sensitivity for CDX2 in metastasis from colorectal adenocarcinomas was 93%; while in SATB2 it was 79%. The combination of CDX2 and SATB2 yielded a sensitivity of 79% and a high specificity of 93%. There was an acceptable level of agreement (=0.64) between the pathologists for both the markers in case of colorectal adenocarcinoma metastasis. CDX2 is a sensitive marker compared to SATB2; while the specificity of combination of CDX2 and SATB2 is high for metastasis from colorectal adenocarcinoma. SATB2 can be used as a supplementary marker along with CDX2 to identify colorectal origin for material received from patients clinically presenting with metastasis.