Effects of glucocorticoid on adipocyte size in human bone marrow
Effects of glucocorticoid on adipocyte size in human bone marrow
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DOI：
10.1007/s00795-007-0367-6
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发表时间：
2007-09-01
影响因子：
1.8
通讯作者：
Hotokebuchi, Takao
中科院分区：
文献类型：
--
作者：
Kitajima, Masaru;Shigematsu, Masamori;Hotokebuchi, Takao
激素性股骨头坏死的发病机制可能与脂代谢有关。成熟的脂肪细胞被认为在脂肪代谢中起着核心作用。本研究的目的是研究类固醇治疗后人股骨头中成熟脂肪细胞的大小。癌骨组织取自20例接受全髋关节置换术的女性股骨头。然后将该骨组织在含有10(-7)或10(-5)M地塞米松的培养液中孵育5天。扫描电子显微镜观察骨髓成熟脂肪细胞，并测量单个脂肪细胞的最大直径。大剂量类固醇治疗后，人骨髓中成熟脂肪细胞的大小增加。类固醇治疗后的最大脂肪细胞体积是对照组的1.5倍。类固醇诱导的骨坏死是已知的，有时发生在大剂量的类固醇治疗之后。这些发现可能提示激素性骨坏死早期的致病因素。
The pathogenesis of corticosteroid-induced femoral head necrosis is assumed to be related to lipid metabolism. Mature fat cells are believed to play a central role in lipid metabolism. The purpose of this study was to investigate the size of mature fat cells in the human femoral head after steroid treatment. Cancerous bone tissue was obtained from the femoral heads of 20 women who had undergone total hip arthroplasty. This bone tissue was subsequently incubated in a medium containing 10(-7) or 10(-5) M dexamethasone for 5 days. Mature fat cells from the bone marrow were observed by scanning electron microscopy, and the largest diameter of individual fat cells was measured. The size of the mature fat cells in human bone marrow increased after high-dose steroid treatment. The largest fat cell volume after steroid treatment was one and one-half times larger than that observed in the control. Steroid-induced osteonecrosis is known to sometimes occur after high-dose steroid treatment. These findings may indicate the pathogenetic factors in the early stage of steroid-induced osteonecrosis.