Possible roles of tumor-associated carbohydrate antigens.
Possible roles of tumor-associated carbohydrate antigens.
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作者：
M. Fukuda
关于碳水化合物作用的研究的最新进展带来了重要的发现，这使我们能够为理解肿瘤相关碳水化合物抗原的作用提供可行的假设。在本报告中，我重点描述这一进展的三个不同方面。我讨论：（a）对病理条件下异常表达的寡糖的免疫反应； (b) 碳水化合物依赖性细胞粘附在肿瘤转移过程中的可能作用； (c)碳水化合物在调节附着这些碳水化合物的蛋白质的功能中的作用。碳水化合物作用的这三个领域可能会成为持续研究的目标，以揭示肿瘤相关碳水化合物的作用。
Recent progress in the studies on the roles of carbohydrates has brought about critical discoveries, which allow us to have working hypotheses for understanding the roles of tumor-associated carbohydrate antigens. In this report, I focus my description on three different aspects of this progress. I discuss: (a) the immunological response to oligosaccharides aberrantly expressed under pathological conditions; (b) possible roles of carbohydrate-dependent cell adhesion during tumor metastasis; and (c) the roles of carbohydrates in modulating the functions of proteins that attach those carbohydrates. These three areas in the roles of carbohydrates will likely be the target for continuous research efforts to reveal the roles of tumor-associated carbohydrates.