The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation.
The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation.
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DOI：
10.3390/ijms19061780
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发表时间：
2018-06-15
影响因子：
5.6
通讯作者：
Chiabrando GA
中科院分区：
文献类型：
--
作者：
Actis Dato V;Chiabrando GA
代谢综合征 (MetS) 是一种非常普遍的疾病，可用于识别心血管疾病和 2 型糖尿病风险较高的个体。这种代谢综合征的特征是生理、代谢和分子改变的结合，例如胰岛素抵抗、血脂异常和中心性肥胖。低密度脂蛋白受体相关蛋白 1（LRP1——LDL 受体家族的成员）是一种内吞和信号传导受体，在多种组织中表达。它参与循环中乳糜微粒残留物的清除，并已被证明在肝脏水平的脂质代谢中发挥关键作用。最近的研究表明，LRP1 参与胰岛素受体 (IR) 运输和细胞内信号传导活动，对脂肪细胞、肌肉细胞和大脑中葡萄糖稳态的调节产生影响。此外，LRP1 具有抑制或维持巨噬细胞炎症的潜力，具体取决于其细胞表达以及细胞外微环境中特定类型配体的存在。在这篇综述中，我们总结了有关组织特异性 LRP1 在脂蛋白和葡萄糖代谢中的作用的现有观点和最新创新，并检查了其介导与 MetS 和动脉粥样硬化相关的炎症过程的能力。
Metabolic syndrome (MetS) is a highly prevalent disorder which can be used to identify individuals with a higher risk for cardiovascular disease and type 2 diabetes. This metabolic syndrome is characterized by a combination of physiological, metabolic, and molecular alterations such as insulin resistance, dyslipidemia, and central obesity. The low-density lipoprotein receptor-related protein 1 (LRP1—A member of the LDL receptor family) is an endocytic and signaling receptor that is expressed in several tissues. It is involved in the clearance of chylomicron remnants from circulation, and has been demonstrated to play a key role in the lipid metabolism at the hepatic level. Recent studies have shown that LRP1 is involved in insulin receptor (IR) trafficking and intracellular signaling activity, which have an impact on the regulation of glucose homeostasis in adipocytes, muscle cells, and brain. In addition, LRP1 has the potential to inhibit or sustain inflammation in macrophages, depending on its cellular expression, as well as the presence of particular types of ligands in the extracellular microenvironment. In this review, we summarize existing perspectives and the latest innovations concerning the role of tissue-specific LRP1 in lipoprotein and glucose metabolism, and examine its ability to mediate inflammatory processes related to MetS and atherosclerosis.
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影响因子：
5.5
作者：
Ganesan R;Henkels KM;Wrenshall LE;Kanaho Y;Di Paolo G;Frohman MA;Gomez-Cambronero J
通讯作者：
Gomez-Cambronero J
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作者：
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作者：
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Lopez-Miranda, Jose
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3.3
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