NEUROFIBROMATOSIS-2 - (BILATERAL ACOUSTIC NEUROFIBROMATOSIS)
NEUROFIBROMATOSIS-2 - (BILATERAL ACOUSTIC NEUROFIBROMATOSIS)
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DOI：
10.1056/nejm198803173181106
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发表时间：
1988-03-17
影响因子：
158.5
通讯作者：
ELDRIDGE, R
中科院分区：
文献类型：
--
作者：
MARTUZA, RL;ELDRIDGE, R
神经纤维瘤病由两种不同的疾病组成，1，2其基因最近被定位在不同的染色体上。3456神经纤维瘤病1，也称为冯雷克林豪森神经纤维瘤病，在美国约有10万人患病。它是一种常见的和潜在的严重遗传性疾病的人类神经系统。1神经纤维瘤病2，也被称为双侧听神经纤维瘤病，影响数千名美国人，并有一个类似的分子起源的一些常见的零星发生的肿瘤的神经系统-脑膜瘤，神经鞘瘤，神经纤维瘤，并可能胶质瘤。治疗困境和基础研究发现. .. . . .
THE neurofibromatoses consist of two distinct disorders,1,2the genes for which have recently been located on separate chromosomes.3456Neurofibromatosis 1, also called von Recklinghausen's neurofibromatosis, affects approximately 100,000 people in the United States. It is a common and potentially serious inherited disorder of the human nervous system.1Neurofibromatosis 2, also known as bilateral acoustic neurofibromatosis, affects several thousand Americans and has a molecular origin similar to that of some of the common sporadically occurring tumors of the nervous system — meningiomas, schwannomas, neurofibromas, and possibly gliomas.3This review discusses the clinical features, diagnostic advances, treatment dilemmas, and basic research findings . . .