The Role of Mir-148a in Cancer.
The Role of Mir-148a in Cancer.
复制标题
Mir-148a 在癌症中的作用
DOI：
10.7150/jca.14616
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发表时间：
2016
影响因子：
3.9
通讯作者：
Peng X
中科院分区：
文献类型：
--
作者：
Li Y;Deng X;Zeng X;Peng X
微小RNA（microRNAs，miRNAs）是一类高度保守的非编码RNA，长度约为19-25个核苷酸。通过与靶mRNA的3'非翻译区（UTR）中的互补位点特异性配对，它们介导转录后沉默。MicroRNA参与了许多生理过程，包括增殖、分化、发育、凋亡和代谢。近年来，大量研究表明miRNA的异常表达与肿瘤的发生密切相关，是目前研究的热点。Mir-148 a在多种癌症中异常表达，并且已被鉴定为在肿瘤发生的分子机制中具有关键作用的致癌或肿瘤抑制因子。本文综述了mir-148 a在胃癌、肝癌、乳腺癌和泌尿生殖道癌的致癌途径中的作用，以及在神经胶质细胞瘤的发生中的作用。研究mir-148 a的功能对于发现新的肿瘤分子标志物和确定潜在的治疗靶点至关重要。
MicroRNAs (miRNAs) are highly conserved noncoding RNAs of about 19-25 nucleotides. Through specifically pairing with complementary sites in 3' untranslated regions (UTRs) of target mRNAs, they mediate post-transcriptional silencing. MicroRNAs have been implicated in many physiological processes including proliferation, differentiation, development, apoptosis, and metabolism. In recent years many studies have revealed that the aberrant expression of miRNA is closely related to oncogenesis and is now an intense field of study. Mir-148a is aberrantly expressed in various cancers and has been identified as an oncogenic or tumor suppressor with crucial roles in the molecular mechanisms of oncogenesis. In this review, we have summarized the role of mir-148a in the oncogenic pathways of gastric, liver, breast and urogenital cancers, and in neurogliocytoma oncogenesis. Studying the functional role of mir-148a is crucial in discovering novel tumor molecular markers and identifying potential therapeutic targets.