Efficiency of Functional Brain Networks and Intellectual Performance
Efficiency of Functional Brain Networks and Intellectual Performance
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DOI：
10.1523/jneurosci.1443-09.2009
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发表时间：
2009-06-10
影响因子：
5.3
通讯作者：
Pol, Hilleke E. Hulshoff
中科院分区：
文献类型：
--
作者：
van den Heuvel, Martijn P.;Stam, Cornelis J.;Pol, Hilleke E. Hulshoff
我们的大脑是一个复杂的网络，信息在空间分布但功能相连的区域之间不断被处理和传输。最近的研究表明，大脑网络的功能连接以一种高效的小世界方式组织起来，表明存在高水平的局部邻域聚类，同时存在更多的远距离连接，确保了整个网络内高水平的全球通信效率。我们功能性大脑的这种高效的网络架构提出了一个问题，即我们大脑功能连接区域的效率与我们的智力水平之间可能存在关联。使用图分析检查大脑网络的整体组织，我们显示静息状态大脑网络的归一化特征路径长度lambda与智商（IQ）之间存在强烈的负相关。这表明，人类的智力表现可能与我们的大脑在多个大脑区域之间整合信息的效率有关。标准化路径长度和智商之间最显著的影响发现在额叶和顶叶区域。我们的研究结果表明，大脑功能网络的整体效率与智力表现之间存在着强烈的正相关关系。
Our brain is a complex network in which information is continuously processed and transported between spatially distributed but functionally linked regions. Recent studies have shown that the functional connections of the brain network are organized in a highly efficient small-world manner, indicating a high level of local neighborhood clustering, together with the existence of more long-distance connections that ensure a high level of global communication efficiency within the overall network. Such an efficient network architecture of our functional brain raises the question of a possible association between how efficiently the regions of our brain are functionally connected and our level of intelligence. Examining the overall organization of the brain network using graph analysis, we show a strong negative association between the normalized characteristic path length lambda of the resting-state brain network and intelligence quotient (IQ). This suggests that human intellectual performance is likely to be related to how efficiently our brain integrates information between multiple brain regions. Most pronounced effects between normalized path length and IQ were found in frontal and parietal regions. Our findings indicate a strong positive association between the global efficiency of functional brain networks and intellectual performance.