Hypertriglyceridemia is associated with an elevated blood viscosity Rosenson: triglycerides and blood viscosity
Hypertriglyceridemia is associated with an elevated blood viscosity Rosenson: triglycerides and blood viscosity
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DOI：
10.1016/s0021-9150(01)00656-6
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发表时间：
2002-04-01
期刊：
影响因子：
5.3
通讯作者：
Tangney, CC
中科院分区：
文献类型：
--
作者：
Rosenson, RS;Shott, S;Tangney, CC
血液粘度升高是心血管疾病的预测因子。血液粘度的主要决定因素是血细胞比容和血浆粘度。血浆甘油三酯升高血浆粘度;然而，在校正其他主要协变量后，血浆甘油三酯对血液粘度的贡献尚未报道。这项针对257名成年受试者的横断面研究评估了空腹血脂、纤维蛋白原、总血清蛋白、红细胞压积和血液粘度之间的相关性。血液粘度在37 ℃下用同轴圆筒微粘度计在100和1 s（-1）的剪切速率下测量。将血液粘度值报告为未校正的测量值和通过回归方程校正至45%血细胞比容的测量值。使用逐步多元回归分析，在100 s（-1）切变率下未校正的血液粘度与甘油三酯、纤维蛋白原、高密度脂蛋白（HDL）胆固醇、血清总蛋白和红细胞压积显著相关。当100 s（-1）时的校正血液粘度为因变量时，与甘油三酯、HDL胆固醇和血清总蛋白存在统计学显著相关性。1 s（-1）时校正的血液粘度与甘油三酯、纤维蛋白原、血清总蛋白和糖尿病的指示变量显著相关。这项研究支持甘油三酯可能导致心血管风险的额外机制。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Elevated blood viscosity is a predictor of cardiovascular disease. The major determinants of blood viscosity are hematocrit and plasma viscosity. Plasma triglycerides elevate plasma viscosity; however, the contribution of plasma triglycerides to blood viscosity after adjustment for other major covariates has riot been reported. This cross-sectional study of 257 adult subjects evaluated the associations between fasting plasma lipids, fibrinogen, total serum protein, hematocrit and blood viscosity. Blood viscosity was measured at 37 degreesC with a coaxial cylinder microviscometer at shear rates of 100 and 1 s(-1). Blood viscosity values are reported both as uncorrected measurements and measurements corrected to a hematocrit of 45% by a regression equation. Uncorrected blood viscosity at a shear rate of 100 s(-1) was significantly associated with triglycerides, fibrinogen, high density lipoprotein (HDL) cholesterol, total serum protein, and hematocrit using stepwise multivariate regression analysis. When corrected blood viscosity at 100 s(-1) was the dependent variable, there were statistically significant associations with triglycerides, HDL cholesterol, and total serum protein. Corrected blood viscosity at 1 s(-1) was significantly associated with triglycerides, fibrinogen, total serum protein, and an indicator variable for diabetes mellitus. This study supports an additional mechanism whereby triglycerides may contribute to cardiovascular risk. (C) 2002 Elsevier science Ireland Ltd. All rights reserved.