Extensive migration of young neurons into the infant human frontal lobe.
Extensive migration of young neurons into the infant human frontal lobe.
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DOI：
10.1126/science.aaf7073
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发表时间：
2016-10-07
期刊：
影响因子：
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通讯作者：
Alvarez-Buylla A
中科院分区：
文献类型：
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作者：
Paredes MF;James D;Gil-Perotin S;Kim H;Cotter JA;Ng C;Sandoval K;Rowitch DH;Xu D;McQuillen PS;Garcia-Verdugo JM;Huang EJ;Alvarez-Buylla A
出生后的最初几个月，当孩子开始与环境互动时，对人类大脑的发育至关重要。人类额叶对于社会行为和执行功能很重要；相对于其他物种，它的体型和复杂性有所增加，但促成这种扩张的过程尚不清楚。我们对死后婴儿大脑的研究揭示了一系列神经元在婴儿期广泛迁移并整合到额叶中。年轻神经元链靠近侧脑室壁并沿着血管切向移动。然后，这些细胞各自分散很长的距离，到达皮质组织，在那里它们分化并形成抑制回路。迟到的中间神经元可能有助于发育可塑性，而其出生后迁移或分化的破坏可能是神经发育障碍的基础。
The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in size and complexity relative to other species, but the processes that have contributed to this expansion are unknown. Our studies of postmortem infant human brains revealed a collection of neurons that migrate and integrate widely into the frontal lobe during infancy. Chains of young neurons move tangentially close to the walls of the lateral ventricles and along blood vessels. These cells then individually disperse long distances to reach cortical tissue, where they differentiate and contribute to inhibitory circuits. Late-arriving interneurons could contribute to developmental plasticity, and the disruption of their postnatal migration or differentiation may underlie neurodevelopmental disorders.