Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease
Comparison of fasting and postprandial plasma lipoproteins in subjects with and without coronary heart disease
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DOI：
10.1016/s0002-9149(01)02047-1
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发表时间：
2001-11-15
影响因子：
2.8
通讯作者：
Rubenstein, JJ
中科院分区：
文献类型：
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作者：
Schaefer, EJ;Audelin, MC;Rubenstein, JJ
对88例冠心病（CHD）患者和88例对照者的空腹（12小时）和餐后（4小时）血浆脂蛋白水平（包括残粒样颗粒（RLP）胆固醇和RLP甘油三酯）进行了测定。所有脂蛋白均通过直接方法进行评估。我们假设冠心病患者在进食高脂肪食物后，其甘油三酯水平、RLP胆固醇和RLP甘油三酯的增加百分比更大。在空腹状态下，病例组甘油三酯、RLP胆固醇、RLP甘油三酯和低密度脂蛋白（LDL）胆固醇水平均显著高于对照组，分别为51%、35%、39%和40%。这些水平在PP状态下分别高出57%、37%、64%和37%。在空腹和PP状态下，平均高密度脂蛋白（HDL）胆固醇值均降低27%。进食后，对照组的甘油三酯、RLP胆固醇和RLP甘油三酯分别增加了64%、71%和290%，而病例组的这些水平分别增加了71%、94%和340%（所有p
Plasma lipoprotein levels, including remnant-like particle (RLP) cholesterol and RLP triglycerides, were assessed in fasting (12 hours) and postprandial (PP) (4 hours after a fat-rich meal) states in 88 patients with coronary heart disease (CHD) and 88 controls. All lipoproteins were assessed by direct methods. We hypothesized that patients with CHD would have greater percent increases in their triglyceride levels, RLP cholesterol, and RLP triglycerides, in response to a fat-rich meal. In the fasting state, triglycerides, RLP cholesterol, RLP triglycerides, and low-density lipoprotein (LDL) cholesterol levels were all significantly higher in cases versus controls by 51%, 35%, 39%, and 40%, respectively. These levels were 57%, 37%, 64%, and 37% higher in the PP state, respectively. Mean high-density lipoprotein (HDL) cholesterol values were 27% lower in cases in both the fasting and PP states. After eating, triglycerides, RLP cholesterol, and RLP triglycerides increased 64%, 71%, and 290% in controls, respectively, whereas in cases these levels increased by 71%, 94%, and 340%, respectively (all p